Bone turnover markers (BTMs) are used widely, in both research and clinical practice. In the
last 20 years, much experience has been gained in measurement and interpretation of these …

Alkaline phosphatase (ALP) is highly expressed in the cells of mineralized tissue and plays
a critical function in the formation of hard tissue. The existing status of this critical enzyme …

Abstract Glucocorticoid (GC)‐induced osteoporosis (GIO) is a concurrent disease commonly
appeared in chronic inflammatory and autoimmune disease patients. Stereoselective …

Abstract Context Atypical femur fractures (AFFs) are serious adverse events associated with
bisphosphonates and often show poor healing. Evidence acquisition We performed a …

This article provides an overview of the current knowledge on hypophosphatasia—a rare
genetic disease of very variable presentation and severity—with a special focus on …

Increased serum levels of alkaline phosphatase (ALP) are widely recognized as a
biochemical marker of many disorders affecting the liver or bone. However, the approach for …

Hypophosphatasia (HPP) is a rare genetic disease characterized by a decrease in the
activity of tissue non-specific alkaline phosphatase (TNSALP). TNSALP is encoded by the …

In adult hypophosphatasia (HPP) patients, elevated lumbar spine dual X-ray absorptiometry
(DXA) values are associated with markers of disease severity and disease-specific fracture …

Bone tissue in vertebrates is essential to performing movements, to protecting internal
organs and to regulating calcium homeostasis. Moreover, bone has also been suggested to …

This review summarizes important information on the ectoenzyme tissue-nonspecific
alkaline phosphatase (TNAP) and gives a brief insight into the symptoms, diagnostics, and …