Recent studies indicate that, in addition to necrosis, apoptosis also plays a role in the
process of tissue damage after myocardial infarction, which has pathological and …

Loss of myocardial cells via apoptosis has been observed in many cardiovascular diseases
and has been shown to contribute to the initiation and progression of heart failure. The Bcl-2 …

Ever since the discovery of free radicals, many hypotheses on the deleterious actions of
reactive oxygen species (ROS) have been proposed. However, increasing evidence …

Transgenic mice with cardiac-restricted overexpression of secretable TNF (MHCsTNF)
develop progressive LV wall thinning and dilation accompanied by an increase in …

The role of the proapototic Bax gene in ischemia-reperfusion (I/R) injury was studied in three
groups of mice: homozygotic knockout mice lacking the Bax gene (Bax−/−), heterozygotic …

Major factors linking mitochondrial dysfunction with myocardial injury are analyzed along
with protective mechanisms elicited by endogenous processes and pharmacological …

Introduction Myocardial infarction (MI) is an ischemic life-threatening disease with
exaggerated oxidative stress state that vigorously damages the cardiomyocyte membrane …

The commitment to programmed cell death involves complex interactions among pro-and
antiapoptotic members of the Bcl-2 family of proteins. The physiological result of a decision …

Purposes Pharmacologic downregulation of Bcl-2, an antiapoptotic protein overexpressed in
cancer, might increase chemosensitivity in acute myeloid leukemia (AML). Herein, we …

Heart attacks, or acute myocardial infarctions (AMI), affect more than one million people in
the US every year. The damage that occurs to the heart by AMI is often permanent and as a …