In any biological system with memory, the state of the system depends on its history.
Epigenetic memory maintains gene expression states through cell generations without a …

Phenotypic plasticity, the ability of cells to reversibly alter their phenotypes in response to
signals, presents a significant clinical challenge to treating solid tumors. Tumor cells utilize …

Interphase chromatin is organized in distinct nuclear sub-compartments, reflecting its degree
of compaction and transcriptional status. In Caenorhabditis elegans embryos, H3K9 …

Multivalent interactions between effector proteins and histone post-translational
modifications are an elementary mechanism of dynamic chromatin signalling. Here we …

Abstract Polycomb (PcG) and Trithorax (TrxG) group proteins give stable epigenetic memory
of silent and active gene expression states, but also allow poised states in pluripotent cells …

A fundamental property of many organisms is an ability to sense, evaluate, and respond to
environmental signals. In some situations, generation of an appropriate response requires …

Epigenetic histone modifications play an important role in the maintenance of different cell
phenotypes. The exact molecular mechanism for inheritance of the modification patterns …

Bromodomains are protein modules adopting conserved helix bundle folds. Some
bromodomain-containing proteins, such as ATPase family AAA domain-containing protein 2 …

The question of how noncoding RNAs are involved in Polycomb group (PcG) and Trithorax
group (TrxG) regulation has been on an extraordinary journey over the last three decades …

Abstract The Polycomb (PcG) and Trithorax (TrxG) group proteins work antagonistically on
several hundred developmentally important target genes, giving stable mitotic memory, but …