Gene essentiality is a founding concept of genetics with important implications in both
fundamental and applied research. Multiple screens have been performed over the years in …

Essential genes encode the processes that are necessary for life. Until recently, commonly
applied binary classifications left no space between essential and non-essential genes. In …

The definition of bacterial essential genes has been widely pursued using different
approaches. Their study has impacted several fields of research such as synthetic biology …

Nitrite-oxidizing bacteria (NOB) are chemolithoautotrophs that catalyze the oxidation of
nitrite to nitrate, which is the second step of aerobic nitrification. In marine ecosystems …

Prediction of essential genes helps to identify a minimal set of genes that are absolutely
required for the appropriate functioning and survival of a cell. The available machine …

Abstract The Alignable Tight Genomic Clusters (ATGCs) database is a collection of closely
related bacterial and archaeal genomes that provides several tools to aid research into …

Abstract The Neutral Theory of Molecular Evolution is considered the most powerful theory
to understand the evolutionary behavior of proteins. One of the main predictions of this …

Essential genes constitute the core of genes which cannot be mutated too much nor lost
along the evolutionary history of a species. Natural selection is expected to be stricter on …

Background Essentiality assays are important tools commonly utilized for the discovery of
gene functions. Growth/no growth screens of single gene knockout strain collections are …

Genome-scale metabolic models usually contain inconsistencies that manifest as blocked
reactions and gap metabolites. With the purpose to detect recurrent inconsistencies in …