Living in an oxygenated environment has required the evolution of effective cellular
strategies to detect and detoxify metabolites of molecular oxygen known as reactive oxygen …

▪ Abstract Molecular chaperones, including the heat-shock proteins (Hsps), are a ubiquitous
feature of cells in which these proteins cope with stress-induced denaturation of other …

All cells count on precise mechanisms that regulate protein homeostasis to maintain a stable
and functional proteome. A progressive deterioration in the ability of cells to preserve the …

It has been known for some 70 years that restricting the food intake of laboratory rats
extends their mean and maximum life span. In addition, such life extension has been …

We have discovered that three longevity mutants of the nematode Caenorhabditis elegans
also exhibit increased intrinsic thermotolerance (Itt) as young adults. Mutation of the age-1 …

The diet known as calorie restriction (CR) is the most reproducible way to extend the
lifespan of mammals. Many of the early hypotheses to explain this effect were based on it …

Life expectancy in the world has increased dramatically during the last century; the number
of older adults is expected to rise while the number of youths will decline in the near future …

Restricting food intake to 50 to 70% of that eaten by ad lib-fed rats and mice markedly
increases longevity, retards age-associated physiological deterioration, and delays and, in …

Molecular chaperones are known to play key roles in the synthesis, transport and folding of
nuclear‐encoded mitochondrial proteins and of proteins encoded by mitochondrial DNA …

Sauna use, sometimes referred to as “sauna bathing,” is characterized by short-term passive
exposure to high temperatures, typically ranging from 45° C to 100° C (113° F to 212° F) …