Background: Diabetes is a multifactorial disease and a major cause for many microvascular
and macrovascular complications. The disease will ultimately lead to high rate mortality if it …

В работе рассмотрены исследования, направленные на выявление маркеров
генотоксичности (хромосомные аберрации, микроядра и повреждения ДНК …

Metformin (MET) is the first-choice antidiabetic drug for type 2 diabetes mellitus treatment. In
this study, the genotoxic potential of MET was evaluated by using chromosome aberrations …

Sitagliptin is an active ingredient of antidiabetic drug used in the treatment of type 2 diabetes
mellitus (T2DM). In this study, the genotoxic effects of sitagliptin were determined in human …

Trazodone and milnacipran are the active antidepressant drugs that are being used in the
treatment of psychiatric disorders. In this study, the in vitro genotoxic effects of trazodone and …

Alzheimer's disease (AD) and diabetes mellitus (DM) are related to abnormal changes in
enzyme activity. While acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are …

Metformin and sitagliptin are hypoglycemic drugs with potential use in cancer treatment.
Evidence indicates that metformin may inhibit the proliferation and growth of various types of …

Although Rosiglitazone (R) is recommended for diabetes therapy, however, it increases the
incidence of osteoporosis. Therefore, this study was conducted to investigate the efficiency …

Vildagliptin and sitagliptin are commonly used antidiabetic drugs. Chromosomal aberration
(CA), sister chromatid exchange (SCE) and cytokinesis-block micronucleus (CBMN) assays …

Abstract Background and Objective Although drugs are powerful therapeutic agents, they
have a range of side effects. These side effects are sometimes cellular and not clinically …