Abstract The claudin18. 2 (CLDN18. 2) protein, an isoform of claudin18, a member of the
tight junction protein family, is a highly selective biomarker with limited expression in normal …

The intestinal epithelium forms a physical barrier assembled by intercellular junctions,
preventing luminal pathogens and toxins from crossing it. The integrity of tight junctions is …

Streptococcus anginosus (S. anginosus) was enriched in the gastric mucosa of patients with
gastric cancer (GC). Here, we show that S. anginosus colonized the mouse stomach and …

The barrier and fence functions of the claudin protein family are fundamental to tissue
integrity and human health. Increasing evidence has linked claudins to signal transduction …

Introduction Gastric cancer remains a formidable challenge in oncology with high mortality
rates and few advancements in treatment. Claudin-18.2 (CLDN18. 2) is a tight junction …

Claudins (CLDNs) are a family of major membrane proteins that form components of tight
junctions. In normal tissues, CLDNs seal the intercellular space in the epithelial sheets to …

Introduction: The gastric mucosa (GM) is the first barrier and vital interface in the stomach
that protects the host from hydrochloric acid in gastric juice and defends against exogenous …

Hepatobiliary and pancreatic diseases are becoming increasingly common worldwide and
associated cancers are prone to recurrence and metastasis. For a more accurate treatment …

Background Gastric cancer (GC) is a major global cause of cancer mortality, with a median
overall survival of just 12 months. CLDN18. 2, a specific isoform of Claudin18 normally …

Claudins are a class of transmembrane proteins in the family of tight junction (TJ) proteins.
The disrupted functioning of claudins has been found to have a role in urolithiasis (Kidney …