Therapeutic options for pulmonary arterial hypertension (PAH) have increased over the last
decades. The advent of pharmacological therapies targeting the prostacyclin, endothelin …

The ATP‐binding cassette (ABC) transporter superfamily is one of the largest membrane
protein families existing in wide spectrum of organisms from prokaryotes to human. ABC …

Abnormal epigenetic patterns correlate with effector T cell malfunction in tumours,,–, but the
cause of this link is unknown. Here we show that tumour cells disrupt methionine …

Background and Purpose Cancer cells exhibit more dependence on iron and enhanced
sensitivity to iron‐dependent, programmed cell death (ferroptosis) than normal cells …

The COVID‐19 pandemic caused by the severe acute respiratory syndrome coronavirus 2
(SARS‐CoV‐2) has overwhelmed healthcare systems requiring the rapid development of …

Drug, alcohol and tobacco use disorders are a global burden affecting millions of people.
Despite decades of research, treatment options are sparse or missing, and relapse rates are …

Background and Purpose The SARS‐COV‐2 pandemic and the global spread of
coronavirus disease 2019 (COVID‐19) urgently call for efficient and safe antiviral treatment …

The first clinically relevant reports of preparations of St. John's wort (SJW), a herbal medicine
with anti‐depressant effects, interacting with other drugs, altering their bioavailability and …

The explosive growth in medical devices, imaging and diagnostics, computing, and
communication and information technologies in drug development and healthcare has …

Background and Purpose The gut microbial metabolite butyrate is linked to the modulation
of metabolic disease. The mechanism by which butyrate effects in atherosclerosis is …