Leishmania is a protozoan parasite of the trypanosomatid family, causing a wide range of
diseases with different clinical manifestations including cutaneous, mucocutaneous and …

Secondary metabolites obtained from natural sources are medicinally relevant molecules.
About one-third of all FDA-approved drugs are derived from or based on natural products …

Anxiety is a natural response to stress, characterized by feelings of worry, fear, or unease.
The current research was conducted to investigate the anxiolytic effect of indirubin (IND) in …

Aims Glycogen synthase kinase 3 beta (GSK3β) link with the mitochondrial Permeability
Transition Pore (mPTP) in cardioprotection is debated. We investigated the role of GSK3β in …

A series of indirubin derivatives hydrochloride were obtained using a convenient and mild
method from indirubin. The newly synthesized compounds and their derivatives were …

Alzheimer's disease (AD) is the most devastating neurodegenerative disorder which alters
the memory of a person. It is a common form of senile dementia characterized by memory …

Chagas disease (CD) is one of the main neglected tropical diseases that promote relevant
socioeconomic impacts in several countries. The therapeutic options for the treatment of CD …

Trypanosomatids are an important group of parasites that predominate in tropical and
subtropical areas of the planet, which cause diseases that are classified as forgotten and …

The protozoan parasite Trypanosoma brucei is the causative agent of human African
trypanosomiasis (HAT). The disease is fatal if it remains untreated, whereas most drug …

Benznidazol and nifurtimox are the unique drugs to have trypanocidal effects which are
used to treat Chagasic patients although both of then exhibit considerable cytotoxicity …