Bone defects combined with tumors, infections, or other bone diseases are challenging in
clinical practice. Autologous and allogeneic grafts are two main traditional remedies, but …

All implanted biomaterials are targets of the host's immune system. While the host
inflammatory response was once considered a detrimental force to be blunted or avoided, in …

Regenerating periodontal bone tissues in the aggravated inflammatory periodontal
microenvironment under diabetic conditions is a great challenge. Here, a polydopamine …

Hydrogel microparticles (HMPs) are promising for biomedical applications, ranging from the
therapeutic delivery of cells and drugs to the production of scaffolds for tissue repair and …

With an increasingly aging society, bone defects and fractures have become significant
threats to human health and quality of life. Currently, autologous and allogeneic bone grafts …

Periodontal disease (PD) is one of the most common inflammatory oral diseases, affecting
approximately 47% of adults aged 30 years or older in the United States. If not treated …

Critical-sized bone defect repair in patients with diabetes mellitus remains a challenge in
clinical treatment because of dysfunction of macrophage polarization and the inflammatory …

Immune response and new tissue formation are important aspects of tissue repair. However,
only a single aspect is generally considered in previous biomedical interventions, and the …

A coordinated interaction between osteogenesis and osteoimmune microenvironment is
essential for successful bone healing. In particular, macrophages play a central regulatory …

Tissue engineering strategies for treating bone loss to date have largely focused on
targeting stem cells or vascularization. Immune cells, including macrophages and T cells …