Biology spans a continuum of length and time scales. Individual experimental methods only
glimpse discrete pieces of this spectrum but can be combined to construct a more holistic …

This thematic review aims to provide an overview of the current state of knowledge about the
occurrence of giant mitochondria or megamitochondria in liver parenchymal cells. Their …

As a model organism, Drosophila is uniquely placed to contribute to our understanding of
how brains control complex behavior. Not only does it have complex adaptive behaviors, but …

Maps of the nervous system that identify individual cells along with their type, subcellular
components and connectivity have the potential to elucidate fundamental organizational …

Mammalian neocortex contains a highly diverse set of cell types. These types have been
mapped systematically using a variety of molecular, electrophysiological and morphological …

We are now in the era of millimeter-scale electron microscopy (EM) volumes collected at
nanometer resolution. Dense reconstruction of cellular compartments in these EM volumes …

Images are at the core of most modern biological experiments and are used as a major
source of quantitative information. Numerous algorithms are available to process images …

As AI systems become increasingly powerful, the need for safe AI has become more
pressing. Humans are an attractive model for AI safety: as the only known agents capable of …

Current spatial transcriptomics methods identify cell states in a spatial context but lack
morphological information. Scanning electron microscopy, in contrast, provides structural …

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