Small changes huge impact: the role of protein posttranslational modifications in cellular homeostasis and disease
TM Karve, AK Cheema - Journal of amino acids, 2011 - Wiley Online Library
Posttranslational modifications (PTMs) modulate protein function in most eukaryotes and
have a ubiquitous role in diverse range of cellular functions. Identification, characterization …
have a ubiquitous role in diverse range of cellular functions. Identification, characterization …
Breaking tolerance to thyroid antigens: changing concepts in thyroid autoimmunity
SM McLachlan, B Rapoport - Endocrine reviews, 2014 - academic.oup.com
Thyroid autoimmunity involves loss of tolerance to thyroid proteins in genetically susceptible
individuals in association with environmental factors. In central tolerance, intrathymic …
individuals in association with environmental factors. In central tolerance, intrathymic …
[HTML][HTML] Glycans as key checkpoints of T cell activity and function
The immune system is highly controlled and fine-tuned by glycosylation, through the
addition of a diversity of carbohydrates structures (glycans) to virtually all immune cell …
addition of a diversity of carbohydrates structures (glycans) to virtually all immune cell …
[PDF][PDF] Virion glycosylation influences mycobacteriophage immune recognition
KG Freeman, AC Robotham, OB Parks, L Abad… - Cell Host & Microbe, 2023 - cell.com
Glycosylation of eukaryotic virus particles is common and influences their uptake, trafficking,
and immune recognition. In contrast, glycosylation of bacteriophage particles has not been …
and immune recognition. In contrast, glycosylation of bacteriophage particles has not been …
Antiviral perspectives for chikungunya virus
D Parashar, S Cherian - BioMed Research International, 2014 - Wiley Online Library
Chikungunya virus (CHIKV) is a mosquito‐borne pathogen that has a major health impact in
humans and causes acute febrile illness in humans accompanied by joint pains and, in …
humans and causes acute febrile illness in humans accompanied by joint pains and, in …
Chikungunya virus-induced arthritis: role of host and viral factors in the pathogenesis
S Amdekar, D Parashar, K Alagarasu - Viral immunology, 2017 - liebertpub.com
Chikungunya virus (CHIKV), a member of Alphavirus genus, is responsible for chikungunya
fever (CHIKF), which is characterized by the presence of fever, rash, myalgia, and arthralgia …
fever (CHIKF), which is characterized by the presence of fever, rash, myalgia, and arthralgia …
Acquired TTP: ADAMTS13 meets the immune system
FC Verbij, R Fijnheer, J Voorberg, N Sorvillo - Blood Reviews, 2014 - Elsevier
The majority of the patients affected by acquired thrombotic thrombocytopenic purpura (TTP)
develop autoantibodies directed towards ADAMTS13 that interfere with its von Willebrand …
develop autoantibodies directed towards ADAMTS13 that interfere with its von Willebrand …
Tumor-associated glycans and immune surveillance
B Monzavi-Karbassi, A Pashov, T Kieber-Emmons - Vaccines, 2013 - mdpi.com
Changes in cell surface glycosylation are a hallmark of the transition from normal to inflamed
and neoplastic tissue. Tumor-associated carbohydrate antigens (TACAs) challenge our …
and neoplastic tissue. Tumor-associated carbohydrate antigens (TACAs) challenge our …
Approaches to mitigate the unwanted immunogenicity of therapeutic proteins during drug development
LI Salazar-Fontana, DD Desai, TA Khan, RC Pillutla… - The AAPS journal, 2017 - Springer
All biotherapeutics have the potential to induce an immune response. This immunological
response is complex and, in addition to antibody formation, involves T cell activation and …
response is complex and, in addition to antibody formation, involves T cell activation and …
[HTML][HTML] Identification of novel virus-specific antigens by CD4+ and CD8+ T cells from asymptomatic HSV-2 seropositive and seronegative donors
D Long, M Skoberne, TM Gierahn, S Larson, JA Price… - Virology, 2014 - Elsevier
Reactivation of latent herpes simplex virus 2 (HSV-2) infections can be characterized by
episodic recurrent genital lesions and/or viral shedding. We hypothesize that infected (HSV …
episodic recurrent genital lesions and/or viral shedding. We hypothesize that infected (HSV …