ABSTRACT Interleukin 10 (IL-10) is a cytokine with potent anti-inflammatory properties that
plays a central role in limiting host immune response to pathogens, thereby preventing …

Abstract Interleukin-10 (IL-10), a cytokine with anti-inflammatory properties, has a central
role in infection by limiting the immune response to pathogens and thereby preventing …

Monocytes are effectors of the inflammatory response to microbes. Human CD14+
monocytes specialize in phagocytosis and production of reactive oxygen species and …

Abstract Lymphocyte activation gene-3 (LAG-3) is a CD4-related transmembrane protein
expressed by regulatory T cells that binds MHC II on APCs. It is shown in this study that …

Mitogen-activated protein kinase (MAPK) phosphatases (MKPs) are protein phosphatases
that dephosphorylate both the phosphothreonine and phosphotyrosine residues on …

One of the most fundamental problems in immunology is the seemingly schizophrenic ability
of the immune system to launch robust immunity against pathogens, while acquiring and …

The MAP kinase signaling cascade Ras/Raf/MEK/ERK has been involved in a large variety
of cellular and physiological processes that are crucial for life. Many pathological situations …

Immune responses to heat shock proteins (Hsp) develop in virtually all inflammatory
diseases; however, the significance of such responses is only now becoming clear. In …

CD4+ T cells producing interleukin-10 (IL-10) and interferon-γ (IFN-γ) are reported in chronic
infections. However, the signals that direct the development of IL-10-producing T helper 1 …

Worldwide, more than a billion people are infected with helminths. These worm infections
generally do not lead to mortality, however, they are chronic in nature and can lead to …