Following fertilization, the two specified gametes must unite to create an entirely new
organism. The genome is initially transcriptionally quiescent, allowing the zygote to be …

The assembly of individual proteins into functional complexes is fundamental to nearly all
biological processes. In recent decades, many thousands of homomeric and heteromeric …

With the growth of protein structure data, the analysis of molecular interactions between
ligands and their target molecules is gaining importance. PLIP, the protein–ligand …

The expansion of introns within mammalian genomes poses a challenge for the production
of full-length messenger RNAs (mRNAs), with increasing evidence that these long AT-rich …

Chromatin structure imposes significant obstacles on all aspects of transcription that are
mediated by RNA polymerase II. The dynamics of chromatin structure are tightly regulated …

Transcription and regulation of genes originate from transcription pre-initiation complexes
(PICs). Their structural and positional organization across eukaryotic genomes is unknown …

Interactions between noncoding RNAs and chromatin proteins play important roles in gene
regulation, but the molecular details of most of these interactions are unknown. Using …

The faithful execution of biological processes requires a precise and carefully orchestrated
set of steps that depend on the proper spatial and temporal expression of genes. Here we …

The Mediator complex is a multi-subunit assembly that appears to be required for regulating
expression of most RNA polymerase II (pol II) transcripts, which include protein-coding and …

African swine fever virus (ASFV) causes hemorrhagic fever in domestic pigs, presenting the
biggest global threat to animal farming in recorded history. Despite the importance of ASFV …