Nucleic acid sensing is a central process in the immune system, with far-reaching roles in
antiviral defense, autoinflammation, and cancer. Z-DNA binding protein 1 (ZBP1) is a sensor …

Recent progress in human and mouse genetics has transformed our understanding of the
molecular mechanisms by which recognition of self double-stranded RNA (self-dsRNA) …

Variants of the RNA-editing enzyme ADAR1 cause Aicardi-Goutières syndrome (AGS), in
which severe inflammation occurs in the brain due to innate immune activation. Here, we …

With the advancement of sequencing technologies and bioinformatics, over than 170
different RNA modifications have been identified. However, only a few of these modifications …

The innate immune system relies on molecular sensors to detect distinctive molecular
patterns, including viral double-stranded RNA (dsRNA), which triggers responses resulting …

Adenosine deaminase acting on RNA 1 (ADAR1) converts adenosine to inosine in double-
stranded RNA (dsRNA) molecules, a process known as A-to-I editing. ADAR1 deficiency in …

The RNA editing enzyme adenosine deaminase acting on RNA 1 (ADAR1) is an essential
regulator of the innate immune response to both cellular and viral double-stranded RNA …

Apoptosis plays a pivotal role in pathogen elimination and maintaining homeostasis.
However, viruses have evolved strategies to evade apoptosis, enabling their persistence …

Adenosine-to-inosine RNA editing, catalyzed by the enzymes ADAR1 and ADAR2, stands
as a pervasive RNA modification. A primary function of ADAR1-mediated RNA editing lies in …

Background Retroviruses and Memory: A recent surprise was the discovery that a retrovirally
derived GAG (group associated antigen) protein called ARC (activity-regulated cytoskeletal …