Lung lipid metabolism participates both in infant and adult pulmonary disease. The lung is
composed by multiple cell types with specialized functions and coordinately acting to meet …

RNA-based medicine is receiving growing attention for its diverse roles and potential
therapeutic capacity. The largest obstacle in its clinical translation remains identifying a safe …

Abstract Aims Coronavirus disease 2019 (COVID-19) can lead to multiorgan damage.
MicroRNAs (miRNAs) in blood reflect cell activation and tissue injury. We aimed to …

Lung emphysema and chronic bronchitis are the two most common causes of chronic
obstructive pulmonary disease. Excess macrophage elastase MMP-12, which is …

Chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) are
chronic, progressive lung ailments that are characterized by distinct pathologies. Early …

Alveolar epithelial type II (AEC2) cells strictly regulate lipid metabolism to maintain surfactant
synthesis. Loss of AEC2 cell function and surfactant production are implicated in the …

Lung alveolar type-II (AT-II) cells produce pulmonary surfactant (PS), consisting of proteins
and lipids. The lipids in PS are primarily responsible for reducing the air-fluid surface tension …

Pulmonary surfactant is a crucial and dynamic lung structure whose primary functions are to
reduce alveolar surface tension and facilitate breathing. Though disruptions in surfactant …

Abstract Type 2 alveolar epithelial (AT2) cells of the lung are fundamental in regulating
alveolar inflammation in response to injury. Impaired mitochondrial long-chain fatty acid β …

Chronic obstructive pulmonary disease (COPD) patients frequently suffer from multiple
comorbidities, resulting in poor outcomes for these patients. Diabetes is observed at a …