Aneuploidy, a genomic alternation characterized by deviations in the copy number of
chromosomes, affects organisms from early development through to aging. Although it is a …

Chromosomal instability (CIN) is a hallmark of cancer and a driver of metastatic
dissemination, therapeutic resistance, and immune evasion. CIN is present in 60–80% of …

The fundamental understanding of how Cancer initiates, persists and then progresses is
evolving. High-resolution technologies, including single-cell mutation and gene expression …

Despite being frequently observed in cancer cells, chromosomal instability (CIN) and its
immediate consequence, aneuploidy, trigger adverse effects on cellular homeostasis that …

Simple Summary The experimental/pathological observation of genome chaos (including
massive and large-scale translocations, chromothripsis, and polyploidy cancer cells) …

Mutations in DNA can be limited to one or a few nucleotides, or encompass larger deletions,
insertions, duplications, inversions and translocations that span long stretches of DNA or …

Aberrant ploidy status is a prominent characteristic in malignant neoplasms. Approximately
90% of solid tumors and 75% of haematopoietic malignancies contain aneuploidy cells, and …

Aneuploidy is a cellular state with an unbalanced chromosome number that deviates from
the usual euploid status. During evolution, elaborate cellular mechanisms have evolved to …

The experimental evolution of microorganisms exposed to extreme conditions can provide
insight into cellular adaptation to stress. Typically, stress-sensitive species are exposed to …

Extreme F2 phenotypes known as transgressive segregants can cause increased or
decreased fitness in hybrids beyond the ranges seen in parental populations. Despite the …