[HTML][HTML] Small extracellular vesicles isolation and separation: Current techniques, pending questions and clinical applications

Y Jia, L Yu, T Ma, W Xu, H Qian, Y Sun, H Shi - Theranostics, 2022 - ncbi.nlm.nih.gov
Extracellular vesicles, especially small extracellular vesicles (sEVs) are now accepted as
important messengers in cell-to-cell communication and as a promising drug delivery …

A review on comparative studies addressing exosome isolation methods from body fluids

TS Martins, M Vaz, AG Henriques - Analytical and Bioanalytical Chemistry, 2023 - Springer
Exosomes emerged as valuable sources of disease biomarkers and new therapeutic tools.
However, extracellular vesicles isolation with exosome-like characteristics from certain …

Principles and problems of exosome isolation from biological fluids

EI Yakubovich, AG Polischouk… - … ), Supplement Series A …, 2022 - Springer
Exosomes, the subclass of small membrane extracellular vesicles, have great diagnostic
and therapeutic potential, but the lack of standardized methods for their efficient isolation …

Advances in analytical technologies for extracellular vesicles

H Yan, Y Li, S Cheng, Y Zeng - Analytical Chemistry, 2021 - ACS Publications
Sensitive early detection, along with effective treatments and solid postoperative monitoring
remain the grand challenges in fighting against human diseases, especially cancer.(1) In …

The exosome: a review of current therapeutic roles and capabilities in human reproduction

M Dimik, P Abeysinghe, J Logan, M Mitchell - Drug Delivery and …, 2023 - Springer
Abstract Exosomes are nano-vesicles (30–150 nm) which may be useful as therapeutic
delivery vehicles and as diagnostic biomarkers. Exosomes are produced naturally within the …

Prostate cancer-derived small extracellular vesicle proteins: the hope in diagnosis, prognosis, and therapeutics

H Chen, B Pang, C Zhou, M Han, J Gong, Y Li… - Journal of …, 2023 - Springer
Current diagnostic tools for prostate cancer (PCa) diagnosis and risk stratification are
insufficient. The hidden onset and poor efficacy of traditional therapies against metastatic …

Global Trends of exosomes application in clinical trials: a Scoping review

M Rahnama, M Heidari, Z Poursalehi… - Stem Cell Reviews and …, 2024 - Springer
Background Exosomes, nano-sized extracellular vesicles, have emerged as a promising
tool for the diagnosis and treatment of various intractable diseases, including chronic …

Unconventional protein secretion dependent on two extracellular vesicles: exosomes and ectosomes

J Meldolesi - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
In addition to conventional protein secretion, dependent on the specific cleavage of signal
sequences, proteins are secreted by other processes, all together called unconventional …

Recent advances in liquid biopsy technologies for cancer biomarker detection

N Soda, K Clack, MJA Shiddiky - Sensors & Diagnostics, 2022 - pubs.rsc.org
Gene mutation is associated with cancer and the dissemination of circulating biomarkers
through the blood represents a vital transitional step that exemplifies the shift from localized …

Development of a Novel DNA Aptamer Targeting Colorectal Cancer Cell‐Derived Small Extracellular Vesicles as a Potential Diagnostic and Therapeutic Agent

BS Cha, YJ Jang, ES Lee, DY Kim… - Advanced …, 2023 - Wiley Online Library
Colorectal cancer (CRC) as the second leading cause of global cancer deaths poses critical
challenges in clinical settings. Cancer‐derived small extracellular vesicles (sEVs), which are …