Smart probes for optical imaging of T cells and screening of anti-cancer immunotherapies

M Bertolini, MS Wong, L Mendive-Tapia… - Chemical Society …, 2023 - pubs.rsc.org
T cells are an essential part of the immune system with crucial roles in adaptive response
and the maintenance of tissue homeostasis. Depending on their microenvironment, T cells …

Near-infrared fluorescence imaging in immunotherapy

Y Ji, C Jones, Y Baek, GK Park, S Kashiwagi… - Advanced drug delivery …, 2020 - Elsevier
Near-infrared (NIR) light possesses many suitable optophysical properties for medical
imaging including low autofluorescence, deep tissue penetration, and minimal light …

Grapefruit-derived nanovectors delivering therapeutic miR17 through an intranasal route inhibit brain tumor progression

X Zhuang, Y Teng, A Samykutty, J Mu, Z Deng… - Molecular Therapy, 2016 - cell.com
The lack of access to the brain is a major obstacle for central nervous system drug
development. In this study, we demonstrate the capability of a grapefruit-derived nanovector …

Theranostic chimeric antigen receptor (CAR)-T cells: Insight into recent trends and challenges in solid tumors

K Kheyrolahzadeh, MR Tohidkia, A Tarighatnia… - Life Sciences, 2023 - Elsevier
Cell therapy has reached significant milestones in various life-threatening diseases,
including cancer. Cell therapy using fluorescent and radiolabeled chimeric antigen receptor …

Thermoresponsive liposomes for photo-triggered release of hypericin cyclodextrin inclusion complex for efficient antimicrobial photodynamic therapy

AA Dayyih, B Gutberlet, E Preis… - … Applied Materials & …, 2022 - ACS Publications
Antimicrobial strategies with high efficacy against bacterial infections are urgently needed.
The development of effective therapies to control bacterial infections is still a challenge …

Rapamycin/DiR loaded lipid-polyaniline nanoparticles for dual-modal imaging guided enhanced photothermal and antiangiogenic combination therapy

J Wang, F Guo, M Yu, L Liu, F Tan, R Yan… - Journal of Controlled …, 2016 - Elsevier
Imaging-guided photothermal therapy (PTT) has promising application for treating tumors.
Nevertheless, so far imaging-guided photothermal drug-delivery systems have been …

The immunoimaging toolbox

AT Mayer, SS Gambhir - Journal of Nuclear Medicine, 2018 - Soc Nuclear Med
The recent clinical success of cancer immunotherapy has renewed interest in the
development of tools to image the immune system. In general, immunotherapies attempt to …

Tumor‐Penetrating Nanotherapeutics Loading a Near‐Infrared Probe Inhibit Growth and Metastasis of Breast Cancer

X He, X Bao, H Cao, Z Zhang, Q Yin… - Advanced Functional …, 2015 - Wiley Online Library
The tumor growth and metastasis is the leading reason for the high mortality of breast
cancer. Herein, it is first reported a deep tumor‐penetrating photothermal nanotherapeutics …

Environment-responsive aza-BODIPY dyes quenching in water as potential probes to visualize the in vivo fate of lipid-based nanocarriers

X Hu, J Zhang, Z Yu, Y Xie, H He, J Qi, X Dong… - … , Biology and Medicine, 2015 - Elsevier
Environment-responsive near-infrared (NIR) aza-BODIPY dyes capable of fluorescence
quenching in water were explored to visualize the in vivo fate of model lipid-based …

Advances in Molecular Imaging Strategies for In Vivo Tracking of Immune Cells

HW Lee, P Gangadaran, S Kalimuthu… - BioMed research …, 2016 - Wiley Online Library
Tracking of immune cells in vivo is a crucial tool for development and optimization of cell‐
based therapy. Techniques for tracking immune cells have been applied widely for …