In primary Sjögren syndrome (pSS), the function of the salivary glands is often considerably
reduced. Multiple innate immune pathways are likely dysregulated in the salivary gland …

Relevant reviews highlight the association between dysfunctional mitochondria and
inflammation, but few studies address the contribution of mitochondria and mitochondria …

Inositol-requiring transmembrane kinase/endoribonuclease 1α (IRE1α) is the most
prominent and evolutionarily conserved endoplasmic reticulum (ER) membrane protein …

Primary Sjögren's syndrome (pSS) is a complex autoimmune disease characterized by
dysfunction of secretory epithelia with only palliative therapy. Patients present with a …

The elevated level of interferon-γ (IFN-γ) in Sjogren's syndrome (SS) triggers salivary gland
epithelial cells (SGEC) death. However, the underlying mechanisms of IFN-γ-induced SGEC …

Objective Altered homeostasis of salivary gland (SG) epithelial cells in Sjögren's syndrome
(SS) could be the initiating factor that leads to inflammation, secretory dysfunction and …

Objective Salivary gland epithelial cells (SGECs) are key cellular drivers in the pathogenesis
of primary Sjögren's syndrome (SS); however, the mechanisms sustaining SGEC activation …

It is well established that distinct cell metabolic alterations strongly contribute to the
modulation of innate and adaptive immune responses. In the past decade the term …

Sjogren's syndrome is an autoimmune disease in middle and old‐aged women with a dry
mucosal surface, which is caused by the dysfunction of secretory glands, such as the oral …

Objective The contribution of activating transcription factor 6α (ATF6α) in rheumatoid arthritis
(RA) pathogenesis, especially on fibroblast-like synoviocytes (FLSs), has been suggested …