The emergence of new viruses and resistant strains of pathogenic microorganisms has
become a powerful stimulus in the search for new drugs. Nucleosides are a promising class …

A substantial portion of metabolism involves transformation of phosphate esters, including
pathways leading to nucleotides and oligonucleotides, carbohydrates, isoprenoids and …

The use of the phosphonate motif featuring a carbon-phosphorous bond as bioisosteric
replacement of the labile P–O bond is widely recognized as an attractive structural concept …

Transition state theory teaches that chemically stable mimics of enzymatic transition states
will bind tightly to their cognate enzymes. Kinetic isotope effects combined with …

Chagas disease, caused by the parasitic protozoan Trypanosoma cruzi, affects over 8
million people worldwide. Current antiparasitic treatments for Chagas disease are ineffective …

Malaria still affects around 200 million people and is responsible for more than 400,000
deaths per year, mostly children in subequatorial areas. This disease is caused by parasites …

Acyclic nucleoside phosphonates (ANPs) that contain a 6-oxopurine base are good
inhibitors of the Plasmodium falciparum (Pf) and Plasmodium vivax (Pv) 6-oxopurine …

Hypoxanthine–guanine–[xanthine] phosphoribosyltransferase (HG [X] PRT) is considered
an important target for antimalarial chemotherapy as it is the only pathway for the synthesis …

Purine-utilizing enzymes (PUEs) are involved in the control of biological actions of nitrogen-
containing bases, purines and pyrimidines, by participating in their catabolism, and this has …

Antiparasitic chemotherapy is an important issue for drug development. Traditionally, novel
compounds with antiprotozoan activities have been identified by screening of compound …