Blocking the biological functions of scaffold proteins and aggregated proteins is a
challenging goal. PROTAC proteolysis-targeting chimaera (PROTAC) technology may be …

The scientific community has shown considerable interest in proteolysis-targeting chimeras
(PROTACs) in the last decade, indicating their remarkable potential as a means of achieving …

Ubiquitylation is a posttranslational modification of proteins that is necessary for a variety of
cellular processes. E1 ubiquitin activating enzyme, E2 ubiquitin conjugating enzyme, and E3 …

Neddylation is the writing of monomers or polymers of neural precursor cells expressed
developmentally down-regulated 8 (NEDD8) to substrate. For neddylation to occur, three …

The TP53 gene encodes the transcription factor and oncosuppressor p53 protein that
regulates a multitude of intracellular metabolic pathways involved in DNA damage repair …

Autophagy is a cellular degradative process that has multiple important actions in cancer.
Autophagy modulation is under consideration as a promising new approach to cancer …

The transcription factor p53 is a key tumor suppressor that is inactivated in almost all
cancers due to either point mutations in the TP53 gene or overexpression of its negative …

Medicinal bioinorganic chemistry is a thriving field of drug research for cancer treatment.
Transition metal complexes coordinated to essential biological scaffolds represent a highly …

Proteolysis targeting chimeras (PROTACs) represent a promising class of hetero-bivalent
molecules that facilitate ubiquitination of a target protein by simultaneously binding and …

PROTACs have emerged as a therapeutic modality for the targeted degradation of proteins
of interest (POIs). Central to PROTAC technology are the E3 ligase recruiters, yet only a few …