Challenges of neuropathic pain: focus on diabetic neuropathy

DC Rosenberger, V Blechschmidt… - Journal of Neural …, 2020 - Springer
Neuropathic pain is a frequent condition caused by a lesion or disease of the central or
peripheral somatosensory nervous system. A frequent cause of peripheral neuropathic pain …

Medicinal plants of the family Lamiaceae in pain therapy: A review

CM Uritu, CT Mihai, GD Stanciu, G Dodi… - Pain Research and …, 2018 - Wiley Online Library
Recently, numerous side effects of synthetic drugs have lead to using medicinal plants as a
reliable source of new therapy. Pain is a global public health problem with a high impact on …

Neuropathic pain: mechanism-based therapeutics

K Bannister, J Sachau, R Baron… - Annual Review of …, 2020 - annualreviews.org
Neuropathic pain (NeP) can result from sources as varied as nerve compression,
channelopathies, autoimmune disease, and incision. By identifying the neurobiological …

Emerging biomarkers, tools, and treatments for diabetic polyneuropathy

GJ Bönhof, C Herder, A Strom, N Papanas… - Endocrine …, 2019 - academic.oup.com
Diabetic neuropathy, with its major clinical sequels, notably neuropathic pain, foot ulcers,
and autonomic dysfunction, is associated with substantial morbidity, increased risk of …

Genome-wide association study of multisite chronic pain in UK Biobank

KJA Johnston, MJ Adams, BI Nicholl, J Ward… - PLoS …, 2019 - journals.plos.org
Chronic pain is highly prevalent worldwide and represents a significant socioeconomic and
public health burden. Several aspects of chronic pain, for example back pain and a severity …

Maximizing treatment efficacy through patient stratification in neuropathic pain trials

R Baron, AH Dickenson, M Calvo, SD Dib-Hajj… - Nature Reviews …, 2023 - nature.com
Abstract Treatment of neuropathic pain remains inadequate despite the elucidation of
multiple pathophysiological mechanisms and the development of promising therapeutic …

Making sense of phantom limb pain

HR Schone, CI Baker, J Katz, L Nikolajsen… - Journal of Neurology …, 2022 - jnnp.bmj.com
Phantom limb pain (PLP) impacts the majority of individuals who undergo limb amputation.
The PLP experience is highly heterogenous in its quality, intensity, frequency and severity …

Developing nociceptor-selective treatments for acute and chronic pain

S Jayakar, J Shim, S Jo, BP Bean, I Singeç… - Science translational …, 2021 - science.org
Despite substantial efforts dedicated to the development of new, nonaddictive analgesics,
success in treating pain has been limited. Clinically available analgesic agents generally …

Association of genetic variants with postsurgical pain: a systematic review and meta-analyses

SG Frangakis, M Maceachern, TA Akbar… - …, 2023 - pmc.ncbi.nlm.nih.gov
Background: Postsurgical pain is a key component of surgical recovery. However, the
genetic drivers of postsurgical pain remain unclear. A broad review and meta-analyses of …

Emerging roles of long non‐coding RNAs in neuropathic pain

Z Li, X Li, X Chen, S Li, IHT Ho, X Liu… - Cell …, 2019 - Wiley Online Library
Neuropathic pain, a type of chronic and potentially disabling pain resulting from primary
injury/dysfunction of the somatosensory nervous system and spinal cord injury, is one of the …