Immunoglobulin light chain gene rearrangements, receptor editing and the development of a self-tolerant antibody repertoire
AM Collins, CT Watson - Frontiers in Immunology, 2018 - frontiersin.org
Discussion of the antibody repertoire usually emphasizes diversity, but a conspicuous
feature of the light chain repertoire is its lack of diversity. The diversity of reported allelic …
feature of the light chain repertoire is its lack of diversity. The diversity of reported allelic …
Long-range regulation of V (D) J recombination
Given their essential role in adaptive immunity, antigen receptor loci have been the focus of
analysis for many years and are among a handful of the most well-studied genes in the …
analysis for many years and are among a handful of the most well-studied genes in the …
Igh and Igk loci use different folding principles for V gene recombination due to distinct chromosomal architectures of pro-B and pre-B cells
Extended loop extrusion across the immunoglobulin heavy-chain (Igh) locus facilitates VH-
DJH recombination following downregulation of the cohesin-release factor Wapl by Pax5 …
DJH recombination following downregulation of the cohesin-release factor Wapl by Pax5 …
On being the right size: antibody repertoire formation in the mouse and human
AM Collins, KJL Jackson - Immunogenetics, 2018 - Springer
The immune systems of all mammals include populations of B cells producing antibodies
with incredibly diverse specificities. Repertoire diversity has been described as the “miracle …
with incredibly diverse specificities. Repertoire diversity has been described as the “miracle …
Molecular basis for differential Igk versus Igh V(D)J joining mechanisms
In developing B cells, V (D) J recombination assembles exons encoding IgH and Igκ
variable regions from hundreds of gene segments clustered across Igh and Igk loci. V, D and …
variable regions from hundreds of gene segments clustered across Igh and Igk loci. V, D and …
Dynamic control of long-range genomic interactions at the immunoglobulin κ light-chain locus
The Igκ locus, which is spread over 3 Mb of genomic DNA and contains> 100 variable (V)
genes, serves as an important model system to study long-range chromatin interactions …
genes, serves as an important model system to study long-range chromatin interactions …
Local chromatin features including PU. 1 and IKAROS binding and H3K4 methylation shape the repertoire of immunoglobulin kappa genes chosen for V (D) J …
V (D) J recombination is essential for the generation of diverse antigen receptor (AgR)
repertoires. In B cells, immunoglobulin kappa (Igκ) light chain recombination follows …
repertoires. In B cells, immunoglobulin kappa (Igκ) light chain recombination follows …
NF-κB and AKT signaling prevent DNA damage in transformed pre-B cells by suppressing RAG1/2 expression and activity
K Ochodnicka-Mackovicova, M Bahjat… - Blood, The Journal …, 2015 - ashpublications.org
In developing lymphocytes, expression and activity of the recombination activation gene
protein 1 (RAG1) and RAG2 endonuclease complex is tightly regulated to ensure ordered …
protein 1 (RAG1) and RAG2 endonuclease complex is tightly regulated to ensure ordered …
Regulation of the Alpha and Delta T Cell Receptor Repertoires
DJ Dauphars - 2021 - search.proquest.com
The adaptive immune system, comprised of B and T lymphocytes, responds with unique
specificity to antigens. Specificity is imparted by the process of V (D) J recombination. During …
specificity to antigens. Specificity is imparted by the process of V (D) J recombination. During …
[PDF][PDF] Mechanisms That Direct Assembly of the T Cell Receptor Alpha Repertoire
ZM Carico - 2017 - dukespace.lib.duke.edu
For effective adaptive immune responses, V (D) J recombination must produce diverse,
clonally distributed B and T cell receptors (BCRs and TCRs) during lymphocyte …
clonally distributed B and T cell receptors (BCRs and TCRs) during lymphocyte …