Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a
dismal prognosis. While immunotherapy has been deemed a breakthrough treatment for …

Surgery and anaesthesia result in a variety of metabolic and endocrine responses, which
result in a generalised state of immunosuppression in the immediate post-operative period …

The immediate perioperative period (days before and after surgery) is hypothesized to be
crucial in determining long-term cancer outcomes: during this short period, numerous …

Evidence suggests that excess perioperative activation of the sympathetic nervous system
and the consequent release of catecholamines (ie, epinephrine and norepinephrine) in the …

Brain metastases are prevalent in various types of cancer and are often terminal, given the
low efficacy of available therapies. Therefore, preventing them is of utmost clinical …

Tumor excision is a necessary life-saving procedure in most solid cancers. However,
surgery and the days before and following it, known as the immediate perioperative period …

Uncertainty regarding the development of postoperative metastatic disease is highly
prevalent. Here we assert that numerous processes that occur during the immediate …

Importance Pancreatic cancer is the third most common cause of cancer death; however,
randomized clinical trials (RCTs) of survival in patients with resectable pancreatic cancer …

Pancreatic ductal adenocarcinoma (PDAC) is highly aggressive, deadly, and is rarely
diagnosed early. Regulatory T cells (Treg) are a multifunctional class of immunosuppressive …

Pancreatic ductal adenocarcinoma (PDAC) is a high fatality cancer with one of the worst
prognoses in solid tumors. Most patients present with late stage, metastatic disease and are …