Global epidemiology, genetic environment, risk factors and therapeutic prospects of mcr genes: A current and emerging update

M Mmatli, NM Mbelle, J Osei Sekyere - Frontiers in Cellular and …, 2022 - frontiersin.org
Background Mobile colistin resistance (mcr) genes modify Lipid A molecules of the
lipopolysaccharide, changing the overall charge of the outer membrane. Results and …

Emerging Transcriptional and Genomic Mechanisms Mediating Carbapenem and Polymyxin Resistance in Enterobacteriaceae: a Systematic Review of Current …

M Mmatli, NM Mbelle, NE Maningi, J Osei Sekyere - MSystems, 2020 - Am Soc Microbiol
The spread of carbapenem-and polymyxin-resistant Enterobacteriaceae poses a significant
threat to public health, challenging clinicians worldwide with limited therapeutic options. This …

Polymyxin resistance in Enterobacterales: overview and epidemiology in the Americas

J Rodríguez-Santiago, P Cornejo-Juárez… - International Journal of …, 2021 - Elsevier
The worldwide spread of carbapenem-and polymyxin-resistant Enterobacterales represents
an urgent public-health threat. However, for most countries in the Americas, the available …

[HTML][HTML] Silent spread of mobile colistin resistance gene mcr-9.1 on IncHI2 'superplasmids' in clinical carbapenem-resistant Enterobacterales

N Macesic, LV Blakeway, JD Stewart, J Hawkey… - Clinical Microbiology …, 2021 - Elsevier
Abstract Objectives mcr-9.1 is a newly described mobile colistin resistance gene. We have
noted its presence in multiple species of carbapenem-resistant Enterobacterales (CRE) from …

Prevalence and traits of mobile colistin resistance gene harbouring isolates from different ecosystems in Africa

MU Anyanwu, COR Okpala, KF Chah… - BioMed research …, 2021 - Wiley Online Library
The mobile colistin resistance (mcr) gene threatens the efficacy of colistin (COL), a last‐line
antibiotic used in treating deadly infections. For more than six decades, COL is used in …

Genomic characterization of multidrug-resistant Salmonella serovar Kentucky ST198 isolated in poultry flocks in Spain (2011–2017)

C Samper-Cativiela, B Diéguez-Roda… - Microbial …, 2022 - microbiologyresearch.org
Salmonella Kentucky is commonly found in poultry and rarely associated with human
disease. However, a multidrug-resistant (MDR) S. Kentucky clone [sequence type (ST) 198] …

Emergence of IncHI2 Plasmids With Mobilized Colistin Resistance (mcr)-9 Gene in ESBL-Producing, Multidrug-Resistant Salmonella Typhimurium and Its …

EL Diaconu, P Alba, F Feltrin, P Di Matteo… - Frontiers in …, 2021 - frontiersin.org
A collection of 177 genomes of Salmonella Typhimurium and its monophasic variant
isolated in 2014–2019 from Italian poultry/livestock (n= 165) and foodstuff (n= 12) …

[HTML][HTML] Characterisation of mcr-4.3 in a colistin-resistant Acinetobacter nosocomialis clinical isolate from Cape Town, South Africa

Y Snyman, S Reuter, AC Whitelaw, L Stein… - Journal of Global …, 2021 - Elsevier
ABSTRACT Objectives Colistin resistance in Acinetobacter spp. is increasing, resulting in
potentially untreatable nosocomial infections. Plasmid-mediated colistin resistance is of …

ESBL-producing Vibrio vulnificus and V. alginolyticus harbour a plasmid encoding ISEc9 upstream of blaCTX-M-55 and qnrS2 isolated from imported seafood

T Nakayama, T Yamaguchi, M Jinnai, Y Kumeda… - Archives of …, 2023 - Springer
In recent years, trade liberalisation has led to the spread of antibiotic-resistant bacteria
(ARB) in food products. Because ARB has reportedly been found in imported foods, the …

Emergence of OXA-48-producing Enterobacter hormaechei in a Swiss companion animal clinic and their genetic relationship to clinical human isolates

V Donà, P Nordmann, S Kittl, S Schuller… - Journal of …, 2023 - academic.oup.com
Background Enterobacter hormaechei producing the carbapenemase OXA-48 was
identified repeatedly in infections in companion animals hospitalized at a Swiss veterinary …