DM (diabetes mellitus) is a metabolic disorder of either absolute or relative insulin
deficiency. Optimized insulin injections remain the mainstay life-sustaining therapy for …

The involvement of CD4+ CD25+ regulatory T cells (Treg) in general immune homeostasis
and protection from autoimmune syndromes is now well established. Similarly, there has …

CD4+ CD25+ Foxp3+ regulatory T cells (T regs) are important for preventing autoimmune
diabetes and are either thymic-derived (natural) or differentiated in the periphery outside the …

Human pancreatic islet transplantation offers diabetic patients tight glucose control but has
low graft survival rates. The immunosuppressive drugs that are administered to graft …

Human corneal endothelial cells (HCECs) have a limited proliferative capacity. Descemet
stripping with automated endothelial keratoplasty (DSAEK) has become the preferred …

Hematopoietic cell transplantation is curative in many patients. However, graft-versus-host
disease (GVHD), triggered by alloreactive donor cells, has remained a major complication …

Abstract Interleukin (IL)–32 was originally identified in natural killer cells and IL-2–activated
human T lymphocytes. As T cells are activated in allogeneic transplantation, we determined …

This review focuses on the role of antigen-specific T cells that mediate active inhibition of
immune responses over the past 35 years since their initial description. The field has …

CD4+ CD25 bright+ FoxP3+ T cells are potent regulators of T-cell reactivity, but their
possible involvement in donor-specific nonresponsiveness after clinical kidney …

Dendritic cells (DCs) are professional antigen presenting cells with the ability to induce and
regulate an immune response. DCs that capture and present antigen under …