The Class III PI3K (phosphoinositide 3-kinase), Vps34 (vacuolar protein sorting 34), was first
described as a component of the vacuolar sorting system in Saccharomyces cerevisiae and …

When ubiquitin (Ub) is attached to membrane proteins on the plasma membrane, it directs
them through a series of sorting steps that culminate in their delivery to the lumen of the …

TSG101 and ALIX both function in HIV budding and in vesicle formation at the multivesicular
body (MVB), where they interact with other Endosomal Sorting Complex Required for …

Cellular membranes enter the lysosomal compartment by endocytosis, phagocytosis, or
autophagy. Within the lysosomal compartment, membrane components of complex structure …

The endosomal sorting complex required for transport (ESCRT) machinery is highly
conserved and its components have been found in all five major supergroups of eukaryotes …

The newly described yeast endosomal sorting complexes required for transport (ESCRT)
protein i ncreased s odium t olerance-1 (Ist1p) binds the late-acting ESCRT proteins …

Human ESCRT-I is a multiprotein complex that plays essential roles in HIV budding and
endosomal protein sorting. All ESCRT-I complexes contain three common subunits …

Since the initial discovery of the endosomal sorting complex required for transport (ESCRT)
pathway, research in this field has exploded. ESCRT proteins are part of the endosomal …

Extracellular vesicles (EVs), and especially exosomes, have been shown to mediate
information exchange between distant cells; this process directly affects the biological …

The zona pellucida is the extracellular coat that surrounds the mammalian oocyte. It forms a
spherical shell of remarkably uniform thickness (5-10 microns in eutherian mammals). The …