Potential, limitations and risks of cannabis-derived products in cancer treatment

HJ Woerdenbag, P Olinga, EA Kok, DAP Brugman… - Cancers, 2023 - mdpi.com
Simple Summary It is easy to find success stories on the internet of patients with cancer who
seem to benefit from using cannabis products. However, scientific substantiation is usually …

Smart drug delivery strategies for cancer therapy

CM López Mendoza… - Frontiers in …, 2022 - frontiersin.org
Chemotherapy is one of the most widely used strategies to fight cancer, although it has
disadvantages such as accumulation in healthy organs and lack of specificity by cancer cells …

Protein binding and anticancer activity of two newly synthesized Schiff base platinum (II) complexes: A theoretical and experimental study

MR Abolhassan, A Divsalar… - Journal of Molecular …, 2023 - Elsevier
Platinum-based complexes are effective chemotherapeutics which are applied in
chemotherapy regimens to treat cancer. The present study is designed to investigate the …

Interaction of the synthesized anticancer compound of the methyl-glycine 1, 10-phenanthroline platinum nitrate with human serum albumin and human hemoglobin …

O Abazari, Z Shafaei, A Divsalar… - Journal of the Iranian …, 2020 - Springer
In the present study, the interaction of the novel synthesized platinum complex named
methyl-glycine 1, 10-phenanthroline platinum nitrate product with two most crucial blood …

Insight into the molecular interaction between the anticancer drug, enzalutamide and human alpha-2-macroglobulin: Biochemical and biophysical approach

MK Zia, T Siddiqui, S Ansari, M Muaz, H Ahsan… - … Acta Part A: Molecular …, 2024 - Elsevier
The drug pharmacokinetics is affected upon binding with proteins, thus making drug-protein
interactions crucial. This study investigated the interaction between enzalutamide and …

Insight into the interactions of proteinase inhibitor-alpha-2-macroglobulin with hypochlorite

T Siddiqui, MK Zia, SS Ali, H Ahsan, FH Khan - International journal of …, 2018 - Elsevier
Hypochlorous acid (HOCl), an active bleaching agent is one of the major oxidant produced
by neutrophils under physiological conditions. It is among one of the most potent reactive …

Interaction of anti-cancer drug-cisplatin with major proteinase inhibitor-alpha-2-macroglobulin: Biophysical and thermodynamic analysis

MK Zia, T Siddiqui, SS Ali, H Ahsan, FH Khan - International journal of …, 2018 - Elsevier
Alpha-2-macroglobulin is a multifunctional, highly abundant, plasma protein which reacts
with a wide variety of molecules and drugs including cisplatin. Cisplatin is commonly used …

Understanding the binding interaction between methotrexate and human alpha-2-macroglobulin: Multi-spectroscopic and computational investigation

MK Zia, T Siddiqui, SS Ali, H Ahsan, FH Khan - Archives of biochemistry …, 2019 - Elsevier
Methotrexate (MTX) is advised in the treatment of solid tumours, hematologic malignancies
and autoimmune disorders. On reaching the circulation, 60% of MTX is bound to the proteins …

Improved efficacy of cisplatin delivery by peanut agglutinin-modified liposomes in non-small cell lung cancer

B Yang, R Kou, H Wang, A Wang… - International …, 2024 - spandidos-publications.com
Globally, non-small cell lung cancer (NSCLC) is a significant threat to human health, and
constitutes> 80% of lung cancer cases. Cisplatin (CDDP), a commonly used drug in clinical …

Human Serum Albumin Labelling with a New BODIPY Dye Having a Large Stokes Shift

VI Raskolupova, TV Popova, OD Zakharova… - Molecules, 2021 - mdpi.com
BODIPY dyes are photostable neutral derivatives of 4, 4-difluoro-4-bora-3a, 4a-diaza-s-
indacene. These are widely used as chemosensors, laser materials, and molecular probes …