Covering: up to 2018 β-Lactones are strained rings that are useful organic synthons and
pharmaceutical warheads. Over 30 core scaffolds of β-lactone natural products have been …

The rise of antibiotic resistance necessitates the search for new platforms for drug
development. Prodrugs are common tools for overcoming drawbacks typically associated …

Mycobacteria share with other actinomycetes the ability to produce large quantities of
triacylglycerol (TAG), which accumulate as intracytoplasmic lipid inclusions (ILI) also known …

Esterase enzymes are a family of hydrolases that catalyze the breakdown and formation of
ester bonds. Esterases have gained a prominent position in today's world's industrial …

A series of 4H-chromen-4-one derivatives obtained by scaffold morphing of the benzofuran
compound, TAM16, were tested for antitubercular activity. Compound 8d was active against …

Tuberculosis (TB) is one of the most threatening diseases for humans, however, the drug
treatment strategy for TB has been stagnant and inadequate, which could not meet current …

Abstract Polyketide synthase 13 (Pks13) is an essential enzyme in the synthesis of mycolic
acids in Mtb. Therefore, Pks13 is a promising drug target for tuberculosis treatment. We used …

The mycobacterial outer membrane, or mycomembrane, is essential for the viability and
virulence of Mycobacterium tuberculosis and related pathogens. The mycomembrane is a …

Serine hydrolases (SHs) comprise a large superfamily of enzymes that play critical roles in
many biological processes. Despite their importance, many SHs remain uncharacterized …

Antimicrobial resistance poses a significant threat to our ability to treat infections. Especially
concerning is the emergence of carbapenem-resistant Enterobacteriaceae (CRE). In the …