This review article provides a historical perspective on the role of purinergic signalling in the
regulation of various subsets of immune cells from early discoveries to current …

Human health is under constant threat of a wide variety of dangers, both self and nonself.
The immune system is occupied with protecting the host against such dangers in order to …

Caspase-8 deficiency in certain cells prompts chronic inflammation. One mechanism
suggested to account for this inflammation is enhanced signaling for necrotic cell death …

In 1929 Drury and Szent-Györgyi published a seminal paper describing the potent actions of
adenine compounds. Some decades later, adenosine 5'-triphosphate (ATP) was proposed …

Adoptive cell therapies require the recovery and expansion of highly potent tumour-
infiltrating lymphocytes (TILs). However, TILs in tumours are rare and difficult to isolate …

Nucleotides are emerging as an ubiquitous family of extracellular signaling molecules. It has
been known for many years that adenosine diphosphate is a potent platelet aggregating …

Upon its release from injured cells, such as infected, transformed, inflamed, or necrotic cells,
extracellular adenosine-5ʹ-triphosphate (ATP) acts as a danger signal that recruits …

The P2X 7 receptor is a ligand-gated cation-selective channel that mediates ATP-induced
apoptosis of cells of the immune system. We and others have shown that P2X 7 is …

The ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1, or CD39) catalyzes the
phosphohydrolysis of extracellular ATP (eATP) and ADP (eADP) released under conditions …

Extracellular ATP and related nucleotides promote a wide range of pathophysiological
responses via activation of cell surface purinergic P2 receptors. Almost every cell type …