Analytical methods in untargeted metabolomics: state of the art in 2015

A Alonso, S Marsal, A Julià - Frontiers in bioengineering and …, 2015 - frontiersin.org
Metabolomics comprises the methods and techniques that are used to measure the small
molecule composition of biofluids and tissues, and is actually one of the most rapidly …

Nutrimetabolomics: an integrative action for metabolomic analyses in human nutritional studies

MM Ulaszewska, CH Weinert… - Molecular nutrition & …, 2019 - Wiley Online Library
The life sciences are currently being transformed by an unprecedented wave of
developments in molecular analysis, which include important advances in instrumental …

Metabolic fate of polyphenols in the human superorganism

J van Duynhoven, EE Vaughan… - Proceedings of the …, 2011 - National Acad Sciences
Dietary polyphenols are components of many foods such as tea, fruit, and vegetables and
are associated with several beneficial health effects although, so far, largely based on …

Effects of pre-analytical processes on blood samples used in metabolomics studies

P Yin, R Lehmann, G Xu - Analytical and bioanalytical chemistry, 2015 - Springer
Every day, analytical and bio-analytical chemists make sustained efforts to improve the
sensitivity, specificity, robustness, and reproducibility of their methods. Especially in targeted …

Metabolomics analysis for biomarker discovery: advances and challenges

MS Monteiro, M Carvalho, ML Bastos… - Current medicinal …, 2013 - ingentaconnect.com
Over the last decades there has been a change in biomedical research with the search for
single genes, transcripts, proteins, or metabolites being substituted by the coverage of the …

Standardizing the experimental conditions for using urine in NMR-based metabolomic studies with a particular focus on diagnostic studies: a review

AH Emwas, C Luchinat, P Turano, L Tenori, R Roy… - Metabolomics, 2015 - Springer
The metabolic composition of human biofluids can provide important diagnostic and
prognostic information. Among the biofluids most commonly analyzed in metabolomic …

Recent and potential developments in the analysis of urine: a review

D Ryan, K Robards, PD Prenzler, M Kendall - Analytica chimica acta, 2011 - Elsevier
Analysis of urine is a widely used diagnostic tool that traditionally measured one or, at most,
a few metabolites. However, the recognition of the need for a holistic approach to …

Application of NMR metabolomics to search for human disease biomarkers

T Gebregiworgis, R Powers - Combinatorial chemistry & high …, 2012 - ingentaconnect.com
Since antiquity, humans have used body fluids like saliva, urine and sweat for the diagnosis
of diseases. The amount, color and smell of body fluids are still used in many traditional …

[HTML][HTML] A primer to nutritional metabolomics by NMR spectroscopy and chemometrics

F Savorani, MA Rasmussen, MS Mikkelsen… - Food research …, 2013 - Elsevier
This paper outlines the advantages and disadvantages of using high throughput NMR
metabolomics for nutritional studies with emphasis on the workflow and data analytical …

Mealtime, temporal, and daily variability of the human urinary and plasma metabolomes in a tightly controlled environment

K Kim, C Mall, SL Taylor, S Hitchcock, C Zhang… - PloS one, 2014 - journals.plos.org
While metabolomics has tremendous potential for diagnostic biomarker and therapeutic
target discovery, its utility may be diminished by the variability that occurs due to …