Macrophages destroy bacteria and other microorganisms through phagocytosis-coupled
antimicrobial responses, such as the generation of reactive oxygen species and the delivery …

Aging is a gradual and irreversible physiological process that significantly increases the
risks of developing a variety of pathologies, including neurodegenerative, cardiovascular …

TRIM proteins are characterized by their conserved N-terminal RING, B-box, and coiled-coil
domains. These proteins are efficient regulators of autophagy, apoptosis, and innate …

Mitochondria are key orchestrators of antiviral responses that serve as platforms for the
assembly and activation of innate immune-signaling complexes. In response to viral …

Mycobacterium tuberculosis is a pathogenic mycobacterium that causes tuberculosis.
Tuberculosis is a significant global health concern that poses numerous clinical challenges …

TRIM14 is an important member of the TRIM family and is widely expressed in a variety of
tissues. Like other members of the TRIM family, TRIM14 is also involved in ubiquitination …

Infectious diseases, such as Mycobacterium tuberculosis (Mtb)-caused tuberculosis (TB),
remain a global threat exacerbated by increasing drug resistance. Host-directed therapy …

Mycobacterium tuberculosis (M. tb) is one of the most successful human pathogens, causing
a severe and widespread infectious disease. The frequent emergence of multidrug-resistant …

Autophagy is a crucial immune defense mechanism that controls the survival and
pathogenesis of M. tb by maintaining cell physiology during stress and pathogen attack. The …

The multigene TRIM family is an important component of the innate immune system. For a
long time, the main function of the genes belonging to this family was believed to be an …