Participation bias in the UK Biobank distorts genetic associations and downstream analyses

T Schoeler, D Speed, E Porcu, N Pirastu… - Nature Human …, 2023 - nature.com
While volunteer-based studies such as the UK Biobank have become the cornerstone of
genetic epidemiology, the participating individuals are rarely representative of their target …

Biobanking with genetics shapes precision medicine and global health

CS Gallagher, GS Ginsburg, A Musick - Nature Reviews Genetics, 2024 - nature.com
Precision medicine provides patients with access to personally tailored treatments based on
individual-level data. However, developing personalized therapies requires analyses with …

Pervasive biases in proxy genome-wide association studies based on parental history of Alzheimer's disease

Y Wu, Z Sun, Q Zheng, J Miao, S Dorn, S Mukherjee… - Nature Genetics, 2024 - nature.com
Almost every recent Alzheimer's disease (AD) genome-wide association study (GWAS) has
performed meta-analysis to combine studies with clinical diagnosis of AD with studies that …

The effects of genetic and modifiable risk factors on brain regions vulnerable to ageing and disease

J Manuello, J Min, P McCarthy… - Nature …, 2024 - nature.com
We have previously identified a network of higher-order brain regions particularly vulnerable
to the ageing process, schizophrenia and Alzheimer's disease. However, it remains …

Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research

N Cai, B Verhulst, OA Andreassen, J Buitelaar… - Molecular …, 2024 - nature.com
Psychiatric disorders are highly comorbid, heritable, and genetically correlated [,,–]. The
primary objective of cross-disorder psychiatric genetics research is to identify and …

Principled distillation of UK Biobank phenotype data reveals underlying structure in human variation

CE Carey, R Shafee, R Wedow, A Elliott… - Nature Human …, 2024 - nature.com
Data within biobanks capture broad yet detailed indices of human variation, but biobank-
wide insights can be difficult to extract due to complexity and scale. Here, using large-scale …

Mobile fNIRS for exploring inter-brain synchrony across generations and time

R Moffat, CE Casale, ES Cross - Frontiers in Neuroergonomics, 2024 - frontiersin.org
While still relatively rare, longitudinal hyperscanning studies are exceptionally valuable for
documenting changes in inter-brain synchrony, which may in turn underpin how behaviors …

Correction for participation bias in the UK Biobank reveals non-negligible impact on genetic associations and downstream analyses

T Schoeler, D Speed, E Porcu, N Pirastu, JB Pingault… - bioRxiv, 2022 - biorxiv.org
While large-scale volunteer-based studies such as the UK Biobank (UKBB) have become
the cornerstone of genetic epidemiology, the study participants are rarely representative of …

[HTML][HTML] Pervasive biases in proxy GWAS based on parental history of Alzheimer's disease

Y Wu, Z Sun, Q Zheng, J Miao, S Dorn, S Mukherjee… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Almost every recent Alzheimer's disease (AD) genome-wide association study (GWAS) has
performed meta-analysis to combine studies with clinical diagnosis of AD with studies that …

The impact of self-report inaccuracy in the UK Biobank and its interplay with selective participation

T Schoeler, JB Pingault, Z Kutalik - Nature Human Behaviour, 2024 - nature.com
Although the use of short self-report measures is common practice in biobank initiatives,
such a phenotyping strategy is inherently prone to reporting errors. To explore challenges …