Colorectal cancer (CRC) is the third most common cancer and the fourth most common
cause of cancer-related death. Most cases of CRC are detected in Western countries, with its …

In recent years, the high heterogeneity of colorectal cancer (CRC) has become evident.
Hence, biomarkers need to be developed that enable the stratification of patients with CRC …

Cancer is associated with mutated genes, and analysis of tumour-linked genetic alterations
is increasingly used for diagnostic, prognostic and treatment purposes. The genetic profile of …

Colorectal cancer (CRC) is a leading cause of death among cancer patients. This
heterogeneous disease is characterized by alterations in multiple molecular pathways …

In most colorectal cancer (CRC) patients, outcome cannot be predicted because tumors with
similar clinicopathological features can have differences in disease progression and …

Current staging systems of cancer are mainly based on the anatomical extent of disease.
They need refinement by biological parameters to improve stratification of patients for tumor …

The prognosis of head and neck squamous cell carcinoma (HNSCC) patients remains poor.
High-throughput sequencing data have laid a solid foundation for identifying genes related …

Objective To review biomarker discovery studies using omics data for patient stratification
which led to clinically validated FDA-cleared tests or laboratory developed tests, in order to …

Transcriptomics, which encompasses assessments of alternative splicing and alternative
polyadenylation, identification of fusion transcripts, explorations of noncoding RNAs …

Importance Decisions regarding adjuvant therapy in patients with stage II colorectal cancer
(CRC) have been among the most challenging and controversial in oncology over the past …