A systematic review of transcriptional dysregulation in Huntington's disease studied by RNA sequencing

B Malla, X Guo, G Senger, Z Chasapopoulou… - Frontiers in …, 2021 - frontiersin.org
Huntington's disease (HD) is a chronic neurodegenerative disorder caused by an expansion
of polyglutamine repeats in exon 1 of the Huntingtin gene. Transcriptional dysregulation …

Alteration of GABA ergic neurotransmission in Huntington's disease

M Garret, Z Du, M Chazalon, YH Cho… - CNS Neuroscience & …, 2018 - Wiley Online Library
Hereditary Huntington's disease (HD) is characterized by cell dysfunction and death in the
brain, leading to progressive cognitive, psychiatric, and motor impairments. Despite …

Progression of basal ganglia pathology in heterozygous Q175 knock‐in Huntington's disease mice

Y Deng, H Wang, M Joni, R Sekhri… - Journal of Comparative …, 2021 - Wiley Online Library
We used behavioral testing and morphological methods to detail the progression of basal
ganglia neuron type‐specific pathology and the deficits stemming from them in male …

Early neurochemical modifications of monoaminergic systems in the R6/1 mouse model of Huntington's disease

E Puginier, R Bharatiya, A Chagraoui, J Manem… - Neurochemistry …, 2019 - Elsevier
Huntington's disease (HD) is a rare, autosomal neurodegenerative disease characterized by
motor and cognitive impairments appearing in adults. The R6/1 mouse model of the disease …

Striatal connectivity in pre‐manifest Huntington's disease is differentially affected by disease burden

L Pini, K Youssov, F Sambataro… - European Journal of …, 2020 - Wiley Online Library
Background and purpose Different amounts of cumulative exposure to the toxic mutant form
of the huntingtin protein might underlie the distinctive pattern of striatal connectivity in pre …

Early alterations of motor learning and corticostriatal network activity in a Huntington's disease mouse model

N Badreddine, F Appaix, G Becq, S Achard, F Saudou… - bioRxiv, 2024 - biorxiv.org
Huntington's disease (HD) is a neurodegenerative disorder that presents motor, cognitive
and psychiatric symptoms as it progresses. Prior to motor symptoms onset, alterations and …

Involvement of Foxp2 in the alterations of the basal ganglia circuitry in Huntington's Disease

E Rodríguez Urgellés - 2022 - diposit.ub.edu
[eng] Huntington's Disease (HD) is an autosomal dominant inherited neurodegenerative
disorder characterized by motor, psychiatric, and cognitive manifestations. The disease is …

[PDF][PDF] Neuropsychologische Testungen bei Patienten mit Morbus Huntington im manifesten Stadium zur Entwicklung von klinisch anwendbaren, prognostischen …

S Buresch - 2022 - openscience.ub.uni-mainz.de
2 oder psychotischen Episoden, Depressionen oder Suizidalität kommen (Kipps et al., 2005;
Rosas et al., 2002; Jenkins et al., 1998; Albin, 1995; Albin et al., 1992). Aufgrund der …

PSC-derived neuronal co-cultures to model corticostriatal connectivity loss and associated phenotypes observed in Huntington's disease

C Casey - 2020 - discovery.ucl.ac.uk
Huntington's disease (HD) is a genetic neurodegenerative disease caused by an expanded
CAG-repeat mutation in exon 1 of the gene encoding huntingtin (HTT) which results in an …

Validating Gpr88 as a new therapeutic target in models of the neuropsychiatric symptoms of Parkinson's Disease

B Galet - 2018 - theses.hal.science
Beyond the motor impairment, Parkinson's disease (PD) is also characterised by an early
appearance of psychiatric symptoms such as apathy, depression and cognitive deficits …