Mutations in genes that encode RNA-binding proteins (RBPs) have emerged as critical
determinants of neurological diseases, especially motor neuron disorders such as …

Cytogenetics of Bone and Soft Tissue Tumors [1]. In view of the remarkable developments in
this field since 1994, both in the cytogenetic and particularly in the molecular genetic …

Many sarcomas and leukemias carry nonrandom chromosomal translocations encoding
tumor-specific mutant fusion transcription factors that are essential to their molecular …

Translocated in liposarcoma, Ewing's sarcoma and TATA-binding protein-associated factor
15 constitute an interesting and important family of proteins known as the TET proteins. The …

Ewing's sarcoma is a highly aggressive bone and soft tissue tumor of children and young
adults. At the molecular genetic level Ewing's sarcoma is characterized by a balanced …

Ewing's sarcoma (ES) and primitive neuroectodermal tumor (PNET) are members of a tumor
family consistently associated with chromosomal translocation and functional fusion of the …

Tumor-associated chromosomal translocations lead to the formation of chimeric fusions
between the EWS gene and one of five different ETS transcription factors in Ewing's family …

Results The mouse TLS gene was disrupted in embryonic stem (ES) cells. The TLS coding
region was interrupted inside exon 8 (immediately upstream of the RNA recognition motif) by …

Tumor development is a complex process resulting from interplay between mutations in
oncogenes and tumor suppressors, host susceptibility factors, and cellular context. Great …

Ewing sarcoma provides an important model for transcription-factor-mediated oncogenic
transformation because of its reliance on the ETS-type fusion oncoprotein EWS/FLI. EWS/FLI …