Matrix metalloproteinases, vascular remodeling, and vascular disease

X Wang, RA Khalil - Advances in pharmacology, 2018 - Elsevier
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that
degrade various proteins in the extracellular matrix (ECM). Typically, MMPs have a …

Matrix metalloproteinases in normal pregnancy and preeclampsia

J Chen, RA Khalil - Progress in molecular biology and translational …, 2017 - Elsevier
Normal pregnancy is associated with marked hemodynamic and uterine changes that allow
adequate uteroplacental blood flow and uterine expansion for the growing fetus. These …

Vascular mechanisms and molecular targets in hypertensive pregnancy and preeclampsia

H Qu, RA Khalil - American Journal of Physiology-Heart and …, 2020 - journals.physiology.org
Preeclampsia is a major complication of pregnancy manifested as hypertension and often
intrauterine growth restriction, but the underlying pathophysiological mechanisms are …

Uterine influences on conceptus development in fertility-classified animals

JGN Moraes, SK Behura, TW Geary… - Proceedings of the …, 2018 - National Acad Sciences
A major unresolved issue is how the uterus influences infertility and subfertility in cattle.
Serial embryo transfer was previously used to classify heifers as high-fertile (HF), subfertile …

Altered matrix metalloproteinase-2 and-9 expression/activity links placental ischemia and anti-angiogenic sFlt-1 to uteroplacental and vascular remodeling and …

W Li, KM Mata, MQ Mazzuca, RA Khalil - Biochemical pharmacology, 2014 - Elsevier
Preeclampsia is a complication of pregnancy manifested as maternal hypertension and
often fetal growth restriction. Placental ischemia could be an initiating event, but the linking …

Survival, growth, and maturation of secondary follicles from prepubertal, young, and older adult rhesus monkeys during encapsulated three-dimensional culture …

J Xu, MP Bernuci, MS Lawson, RR Yeoman… - …, 2010 - rep.bioscientifica.com
Aromatase is the enzyme complex that catalyses the synthesis of oestrogens from
androgens, and therefore it has unique potential to influence the physiological balance …

[PDF][PDF] Increase of essential amino acids in the bovine uterine lumen during preimplantation development

AE Groebner, I Rubio-Aliaga, K Schulke… - Reproduction, 2011 - d-nb.info
Amino acids (AAs) are crucial for the developing conceptus prior to implantation. To provide
insights into the requirements of the bovine embryo, we determined the AA composition of …

The pseudogene TUSC2P promotes TUSC2 function by binding multiple microRNAs

ZJ Rutnam, WW Du, W Yang, X Yang… - Nature communications, 2014 - nature.com
Various non-coding regions of the genome, once presumed to be 'junk'DNA, have recently
been found to be transcriptionally active. In particular, pseudogenes are now known to have …

Decreased uterine vascularization and uterine arterial expansive remodeling with reduced matrix metalloproteinase-2 and-9 in hypertensive pregnancy

C Lin, H He, N Cui, Z Ren, M Zhu… - American Journal of …, 2020 - journals.physiology.org
Normal pregnancy involves extensive remodeling of uterine and spiral arteries and matrix
metalloproteinases (MMPs)-mediated proteolysis of extracellular matrix (ECM) …

Effect of cytokinesis inhibitors, DMSO and the timing of oocyte activation on mouse cloning using cumulus cell nuclei

T Wakayama, R Yanagimachi - Reproduction, 2001 - rep.bioscientifica.com
Ammonium is generated in culture media by the spontaneous deamination of amino acids at
37° C and through the metabolism of amino acids by human embryos. The appearance of …