Sarcopenia refers to the loss of muscle strength and mass in older individuals and is a major
determinant of fall risk and impaired ability to perform activities of daily living, often leading …

Many factors have contributed to rendering frailty an emerging, relevant, and very popular
concept. First, many pandemics that have affected humanity in history, including COVID-19 …

Abstract Background and Aims Previous studies found that frailty was an important risk factor
for cardiovascular disease (CVD). However, previous studies only focused on baseline …

Background Observational studies have demonstrated a strong bidirectional association
between frailty and depression, but it remains unclear whether this association reflects …

Objectives Although observational studies have reported the association between frailty and
mental disorders, the causality remains unclear. We aimed to evaluate the bidirectional …

Cross-sectional studies have demonstrated strong associations between physical frailty and
depression. However, the evidence from prospective studies is limited. Here, we analyze …

Background Previous observational studies have suggested the association between
rheumatoid arthritis (RA) and frailty. However, it remains obscure whether this association is …

A thorough understanding and identification of potential determinants leading to frailty are
imperative for the development of targeted interventions aimed at its prevention or …

Many diseases show patterns of co-occurrence, possibly driven by systemic dysregulation of
underlying processes affecting multiple traits. We have developed a method (treeLFA) for …

Background Recent insights suggest that remnant cholesterol (RC) plays a role in cellular
senescence, yet its specific contribution to frailty remains indeterminate. Through the …