Function of renal nerves in kidney physiology and pathophysiology

JW Osborn, R Tyshynsky… - Annual review of …, 2021 - annualreviews.org
Renal sympathetic (efferent) nerves play an important role in the regulation of renal function,
including glomerular filtration, sodium reabsorption, and renin release. The kidney is also …

Hypertension: physiology and pathophysiology

JE Hall, JP Granger, JM do Carmo… - Comprehensive …, 2012 - Wiley Online Library
Despite major advances in understanding the pathophysiology of hypertension and
availability of effective and safe antihypertensive drugs, suboptimal blood pressure (BP) …

Renal sympathetic denervation for treatment of drug-resistant hypertension: one-year results from the Symplicity HTN-2 randomized, controlled trial

MD Esler, H Krum, M Schlaich, RE Schmieder… - Circulation, 2012 - Am Heart Assoc
Background—Renal sympathetic nerve activation contributes to the pathogenesis of
hypertension. Symplicity HTN-2, a multicenter, randomized trial, demonstrated that catheter …

Methods and systems for thermally-induced renal neuromodulation

A Wu, BJ Clark, E Thai, N Zadno, D Zarins - US Patent 9,345,900, 2016 - Google Patents
Methods and system are provided for thermally-induced renal neuromodulation. Thermally-
induced renal neuromodulation may be achieved via direct and/or via indirect application of …

A randomized comparison of pulmonary vein isolation with versus without concomitant renal artery denervation in patients with refractory symptomatic atrial fibrillation …

E Pokushalov, A Romanov, G Corbucci… - Journal of the American …, 2012 - jacc.org
Objectives: The aim of this prospective randomized study was to assess the impact of renal
artery denervation in patients with a history of refractory atrial fibrillation (AF) and drug …

Renal denervation in moderate to severe CKD

D Hering, F Mahfoud, AS Walton, H Krum… - Journal of the …, 2012 - journals.lww.com
Sympathetic activation contributes to the progression of CKD and is associated with adverse
cardiovascular outcomes. Ablation of renal sympathetic nerves reduces sympathetic nerve …

Devices, systems and methods for evaluation and feedback of neuromodulation treatment

S Ballakur, R Beetel, P Friedrichs, A Wu… - US Patent …, 2015 - Google Patents
(60) Provisional application No. 61/406.531, filed on Oct. 25, 2010, provisional application
No. 61/528,108, Primary Examiner—Amanda Patton filed on Aug. 26, 2011, provisional …

ESH position paper: renal denervation–an interventional therapy of resistant hypertension

RE Schmieder, J Redon, G Grassi… - Journal of …, 2012 - journals.lww.com
Abstract Experts from the European Society of Hypertension prepared this position paper in
order to summarize current evidence, unmet needs and practical recommendations on the …

Multi-directional deflectable catheter apparatuses, systems, and methods for renal neuromodulation

A Wu, BJ Clark, D Zarins, E Thai, KJ Michlitsch… - US Patent …, 2014 - Google Patents
2010-11-01 Assigned to ARDIAN, INC. reassignment ARDIAN, INC. ASSIGNMENT OF
ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: CLARK, BENJAMIN …

Controlled tissue ablation

Y Gross - US Patent 10,004,557, 2018 - Google Patents
A catheter (28) has a distal portion that comprises an electrode unit (22) and an ablation unit
(24). A control unit (32) is configured:(i) to receive a preliminary blood pressure value …