Necroptosis is generally considered as an inflammatory cell death form. The core regulators
of necroptotic signaling are receptor‐interacting serine–threonine protein kinases 1 (RIPK1) …

Isolated airway smooth muscle has been extensively investigated since 1840 to understand
the pharmacology of airway diseases. There has often been poor predictability from murine …

Das Management von Asthma hat sich in den letzten Jahrzehnten fundamental gewandelt.
Die vorliegende Leitlinie zur Diagnostik und Therapie von Asthma wurde für pneumologisch …

Longitudinal studies have demonstrated that altered indices of airway function, assessed
shortly after birth, are a risk factor for the subsequent development of wheezing illnesses …

Introduction: Patients can have features of both chronic obstructive pulmonary disease
(COPD) and asthma. However, there is still no consensus how to precisely define this …

Background Asthma is stratified into type 2-high and type 2-low inflammatory phenotypes.
Limited success has been achieved in developing drugs that target type 2-low inflammation …

Background Ventilation heterogeneity is a feature of asthma and indicates small airway
disease. Nuclear imaging methods assess ventilation heterogeneity which can facilitate …

Background: The aim of this review is to summarize the current evidence regarding small
airway disease in asthma, focusing on recent advances in small airway pathophysiology …

Background Recent evidence suggests that insulin resistance affects asthma outcomes.
However, the effect of the homeostatic measure of insulin resistance (HOMA-IR) on airway …

ABSTRACT Introduction Approximately 3–10% of people with asthma have severe asthma
(SA). Patients with SA have greater impairment in daily life and much higher costs. Even if …