The release and extracellular action of ATP are a widespread mechanism for cell-to-cell
communication in living organisms through activation of P2X and P2Y receptors expressed …

Therapeutically controlling chronic progression in multiple sclerosis (MS) remains a major
challenge. MS progression is defined as a steady loss of parenchymal and functional …

Extracellular ATP can be a danger signal, but its role in striatal circuits afflicted in
Parkinson's disease (PD) is unclear and was now investigated. ATP was particularly …

The purinergic pathway mediates both pro-inflammatory and anti-inflammatory responses,
whereas the breakdown of adenosine triphosphate (ATP) is in a critical equilibrium. Under …

ATP signaling and surface P2X4 receptors are upregulated selectively in neurons and/or
glia in various CNS disorders including anxiety, chronic pain, epilepsy, ischemia, and …

The family of ligand-gated ion channels known as P2X receptors were discovered several
decades ago. Since the cloning of the seven P2X receptors (P2X1-P2X7), a huge research …

Prostate cancer (PCa) is the most frequently diagnosed cancer in men, causing
considerable morbidity and mortality. The P2X4 receptor (P2X4R) is the most ubiquitously …

The purinergic signaling system, including P2 receptors, plays an important role in various
central nervous system (CNS) disorders. Over the last few decades, a substantial amount of …

LncRNAs are important regulators of quantitative and qualitative features of the
transcriptome. We have used QTL and other statistical analyses to identify a gene …

The deleterious effects of alcohol use disorders (AUDs) on human health have been
documented worldwide. The enormous socioeconomic burden coupled with lack of …