Background: Preservation of brain health has emerged as a leading public health priority for
the aging world population. Advances in neurovascular biology have revealed an intricate …

Hypertension affects a significant proportion of the adult and aging population and
represents an important risk factor for vascular cognitive impairment and late-life dementia …

Cerebral small vessel disease (CSVD) has emerged as a common factor driving age-
dependent diseases, including stroke and dementia. CSVD-related dementia will affect a …

Importance Little is known about the associations of strict blood pressure (BP) control with
microstructural changes in small vessel disease markers. Objective To investigate the …

A large interventional trial, the Systolic Blood Pressure Intervention Trial sub-study termed
Memory and Cognition in Decreased Hypertension (SPRINT-MIND), found reduced risk of …

Background: The potential benefits or harms of intensive systolic blood pressure (BP) control
on cognitive function and cerebral blood flow in individuals with low diastolic blood pressure …

While greater and higher quality epidemiological and experimental evidence is needed to
unequivocally confirm their causal link with ADRD and/or unravel the underlying …

Background Blood pressure variability (BPV) is predictive of cerebrovascular disease and
dementia, possibly though cerebral hypoperfusion. Higher BPV is associated with cerebral …

This study evaluated the association between systemic arterial blood pressure and cerebral
perfusion in 740 participants of the UK's largest tri-ethnic study with measurements of …

Background: Recent observational studies suggest higher blood pressure (BP) variability
(BPV) is associated with Alzheimer's disease (AD) biomarkers amyloid-beta (Aβ) and tau …