Life's origin entails enclosing a compartment to hoard material, energy, and information. The
envelope necessarily comprises amphipaths, such as prebiotic fatty acids, to partition the …

Mechanosensitive (MS) ion channels are a common mechanism for perceiving and
responding to mechanical force. This class of mechanoreceptors is capable of transducing …

Capillaries are equipped to sense neurovascular coupling agents released onto the outer
wall of a capillary, translating these external signals into electrical/Ca2+ changes that play a …

Mechanotransduction has an important role in physiology. Biological processes including
sensing touch and sound waves require as-yet-unidentified cation channels that detect …

Canonical inflammasome activation induces a caspase-1/gasdermin D (Gsdmd)–dependent
lytic cell death called pyroptosis that promotes antimicrobial host defense but may contribute …

The ability to sense and respond to a wide variety of mechanical stimuli—gravity, touch,
osmotic pressure, or the resistance of the cell wall—is a critical feature of every plant cell …

Isothermal titration calorimetry (ITC) is a biophysical technique for measuring the formation
and dissociation of molecular complexes and has become an invaluable tool in many …

The nucleus houses, organizes, and protects chromatin to ensure genome integrity and
proper gene expression, but how the nucleus adapts mechanically to changes in the …

Cells perceive force through a variety of molecular sensors, of which the mechanosensitive
ion channels are the most efficient and act the fastest. These channels apparently evolved to …

PIEZO1 and PIEZO2 are mechanosensitive cation channels that are highly expressed in
numerous tissues throughout the body and exhibit diverse, cell-specific functions in multiple …