Our understanding of the genetic mechanisms that underlie biological processes has relied
extensively on loss-of-function (LOF) analyses. LOF methods target DNA, RNA or protein to …

Rho-class small GTPases are implicated in basic cellular processes at nearly all brain
developmental steps, from neurogenesis and migration to axon guidance and synaptic …

Exocytosis of cytotoxic granules (CG) by lymphocytes is required for the elimination of
infected and malignant cells. Impairments in this process underly a group of diseases with …

The correct wiring of neuronal circuits depends on outgrowth and guidance of neuronal
processes during development. In the past two decades, great progress has been made in …

During cytokinesis, animal cells rapidly remodel the equatorial cortex to build an aligned
array of actin filaments called the contractile ring. Local reorientation of filaments by active …

Anillin (ANLN), an actin-binding protein, reportedly plays a vital role in cell proliferation and
migration, particularly in cytokinesis. Although there have been findings pointing to a …

Cytokinesis is the last step of cell division that partitions the cellular organelles and
cytoplasm of one cell into two. In animal cells, cytokinesis requires Rho-GTPase-dependent …

Remodeling of the intracellular cytoskeleton plays a key role in accelerating tumor growth
and metastasis. Targeting different cytoskeletal elements is important for existing and future …

In view of increased life expectancy the risk for disturbed integrity of genetic information
increases. This inevitably holds the implication for higher incidence of age-related diseases …

The formation of the nervous system and its striking complexity is a remarkable feat of
development. C. elegans served as a unique model to dissect the molecular events in …