Unprecedented advances have been made in cancer treatment with the use of immune
checkpoint blockade (ICB). However, responses are limited to a subset of patients, and …

Oncolytic viruses (OVs) have attracted growing awareness in the twenty-first century, as they
are generally considered to have direct oncolysis and cancer immune effects. With the …

The adoptive transfer of T cells that are engineered to express chimeric antigen receptors
(CARs) has shown remarkable success in treating B cell malignancies but only limited …

Melanoma, a skin cancer that develops from pigment cells, has been studied intensively,
particularly in terms of the immune response to tumours, and has been used as a model for …

Chimeric antigen receptor (CAR) T cells are ineffective against solid tumors with
immunosuppressive microenvironments. To overcome suppression, we engineered circuits …

T-cell-based immunotherapies hold promise for the treatment of many types of cancer, with
three approved products for B-cell malignancies and a large pipeline of treatments in clinical …

Immunotherapies have shown remarkable, albeit tumor-selective, therapeutic benefits in the
clinic. Most patients respond transiently at best, highlighting the importance of …

The immune system is a fascinating world of cells, soluble factors, interacting cells, and
tissues, all of which are interconnected. The highly complex nature of the immune system …

Immune evasion is a hallmark of KRAS-driven cancers, but the underlying causes remain
unresolved. Here, we use a mouse model of pancreatic ductal adenocarcinoma to inactivate …

Cytokines exert powerful immunomodulatory effects that are critical to physiology and
pathology in humans. The application of natural cytokines in clinical studies has not been …