The metabolic syndrome

MA Cornier, D Dabelea, TL Hernandez… - Endocrine …, 2008 - academic.oup.com
Abstract The “metabolic syndrome”(MetS) is a clustering of components that reflect
overnutrition, sedentary lifestyles, and resultant excess adiposity. The MetS includes the …

Biology's response to dieting: the impetus for weight regain

PS MacLean, A Bergouignan… - American Journal …, 2011 - journals.physiology.org
Dieting is the most common approach to losing weight for the majority of obese and
overweight individuals. Restricting intake leads to weight loss in the short term, but, by itself …

Ectopic fat and insulin resistance: pathophysiology and effect of diet and lifestyle interventions

M Snel, JT Jonker, J Schoones, H Lamb… - International journal …, 2012 - Wiley Online Library
The storage of triglyceride (TG) droplets in nonadipose tissues is called ectopic fat storage.
Ectopic fat is associated with insulin resistance and type 2 diabetes mellitus (T2DM). Not the …

[PDF][PDF] Orlistat for overweight subjects with nonalcoholic steatohepatitis: a randomized, prospective trial

SA Harrison, W Fecht, EM Brunt… - …, 2009 - Wiley Online Library
The aim of this study was to determine if orlistat, an inhibitor of fat absorption, combined with
caloric restriction in overweight subjects with nonalcoholic steatohepatitis results in weight …

Lipid accumulation in non-adipose tissue and lipotoxicity

NA Van Herpen, VB Schrauwen-Hinderling - Physiology & behavior, 2008 - Elsevier
Obesity is a well-known risk factor for the development of type 2 diabetes mellitus and
cardiovascular disease. Importantly, obesity is not only associated with lipid accumulation in …

Nonalcoholic fatty liver disease: a review and update

JR Lewis, SR Mohanty - Digestive diseases and sciences, 2010 - Springer
The spectrum of nonalcoholic fatty liver disease (NAFLD) ranges from asymptomatic
steatosis to nonalcoholic steatohepatitis (NASH) and cirrhosis. Hepatic steatosis occurs …

Diagnosis and therapy of nonalcoholic steatohepatitis

DM Torres, SA Harrison - Gastroenterology, 2008 - Elsevier
The increasing prevalence of obesity, insulin resistance, and the metabolic syndrome has
significant implications for the future of chronic liver disease. The resultant increase in the …

Gastric bypass and banding equally improve insulin sensitivity and β cell function

D Bradley, C Conte, B Mittendorfer… - The Journal of …, 2012 - Am Soc Clin Investig
Bariatric surgery in obese patients is a highly effective method of preventing or resolving
type 2 diabetes mellitus (T2DM); however, the remission rate is not the same among …

Weight loss in obese adults 65 years and older: a review of the controversy

DL Waters, AL Ward, DT Villareal - Experimental gerontology, 2013 - Elsevier
Obesity in older adults is ubiquitous in many developed countries and is related to various
negative health outcomes, making it an important public health target for intervention …

Effects of canagliflozin on body composition and hepatic fat content in type 2 diabetes patients with non‐alcoholic fatty liver disease

M Inoue, A Hayashi, T Taguchi, R Arai… - Journal of diabetes …, 2019 - Wiley Online Library
Abstract Aims/Introduction Non‐alcoholic fatty liver disease is frequently associated with
type 2 diabetes, and constitutes an important risk factor for the development of hepatic …