Modulators of microglial activation and polarization after intracerebral haemorrhage

X Lan, X Han, Q Li, QW Yang, J Wang - Nature Reviews Neurology, 2017 - nature.com
Intracerebral haemorrhage (ICH) is the most lethal subtype of stroke but currently lacks
effective treatment. Microglia are among the first non-neuronal cells on the scene during the …

Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage

H Zhu, Z Wang, J Yu, X Yang, F He, Z Liu, F Che… - Progress in …, 2019 - Elsevier
Intracerebral hemorrhage (ICH) is a common and severe cerebrovascular disease that has
high mortality. Few survivors achieve self-care. Currently, patients receive only symptomatic …

Erythropoietin: emerging role of erythropoietin in neonatal neuroprotection

V Rangarajan, SE Juul - Pediatric neurology, 2014 - Elsevier
Background In the last two decades, there has been considerable evolution in
understanding the role of erythropoietin in neuroprotection. Erythropoietin has both …

Therapeutic modulation of the phosphatidylinositol 3-kinases (PI3K) pathway in cerebral ischemic injury

H Khan, A Singh, K Thapa, N Garg, AK Grewal… - Brain Research, 2021 - Elsevier
The cerebral ischemic reperfusion injury may leads to morbidity and mortality in patients.
phosphatidylinositol 3-kinase (PI3K) signaling pathway has been believed to work in …

Neuroprotective therapies for spontaneous intracerebral hemorrhage

KN Kearns, N Ironside, MS Park, BB Worrall… - Neurocritical Care, 2021 - Springer
Patients who survive the initial ictus of spontaneous intracerebral hemorrhage (ICH) remain
vulnerable to subsequent injury of the perilesional parenchyma by molecular and cellular …

Circulating endothelial cell-derived extracellular vesicles mediate the acute phase response and sickness behaviour associated with CNS inflammation

Y Couch, N Akbar, J Roodselaar, MC Evans… - Scientific reports, 2017 - nature.com
Brain injury elicits a systemic acute-phase response (APR), which is responsible for co-
ordinating the peripheral immunological response to injury. To date, the mechanisms …

EPO and EPO-receptor system as potential actionable mechanism for the protection of brain and heart in refractory epilepsy and SUDEP

J Auzmendi, MB Puchulu… - Current …, 2020 - ingentaconnect.com
The most important activity of erythropoietin (EPO) is the regulation of erythrocyte production
by activation of the erythropoietin receptor (EPO-R), which triggers the activation of anti …

[HTML][HTML] Protective effects of oleuropein against cerebral ischemia/reperfusion by inhibiting neuronal apoptosis

W Zhang, X Liu, Q Li - … medical journal of experimental and clinical …, 2018 - ncbi.nlm.nih.gov
Protective Effects of Oleuropein Against Cerebral Ischemia/Reperfusion by Inhibiting Neuronal
Apoptosis - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI Homepage …

Different responses after intracerebral hemorrhage between young and early middle-aged mice

K Kinoshita, R Ohtomo, H Takase, G Hamanaka… - Neuroscience …, 2020 - Elsevier
Although aging is a major risk factor for intracerebral hemorrhage (ICH), there are very few
studies comparing ICH pathology between young and early middle-aged mice. In this study …

Hydrochloride fasudil attenuates brain injury in ICH rats

L Li, X Lou, K Zhang, F Yu, Y Zhao… - Translational …, 2020 - degruyter.com
Aim The aim of this study was to investigate the neuroprotective effects of hydrochloride
fasudil (HF) in rats following intracerebral hemorrhage (ICH). Methods Male Wistar rats were …