Pharmaceutical targeting of the brain

IA Krizbai, æ# 129; dám Nyúl-Tóth… - Current …, 2016 - benthamdirect.com
Besides being indispensable for the protection and nutrition of the central nervous system
(CNS), blood-brain barrier (BBB)-forming cerebral endothelial cells (CECs) have a major …

Therapeutic ultrasound: an innovative approach for targeting neurological disorders affecting the basal ganglia

A Singh, JNJ Reynolds - Frontiers in neuroanatomy, 2024 - frontiersin.org
The basal ganglia are involved in motor control and action selection, and their impairment
manifests in movement disorders such as Parkinson's disease (PD) and dystonia, among …

Quantification of kinetic rate constants for transcytosis of polymeric nanoparticle through blood-brain barrier

AI Khan, Q Lu, D Du, Y Lin, P Dutta - Biochimica et Biophysica Acta (BBA) …, 2018 - Elsevier
Background Polymeric nanoparticles (PNP) have received significant amount of interests for
targeted drug delivery across the blood-brain barrier (BBB). Experimental studies have …

Dynamic control of neurochemical release with ultrasonically-sensitive nanoshell-tethered liposomes

SM Mackay, DMA Myint, RA Easingwood… - Communications …, 2019 - nature.com
The unique surface plasmon resonance of hollow gold nanoshells can be used to achieve
drug release from liposomes upon laser stimulation, and adapted to mimic the intricate …

2 种磨料应用于水射流剥离3PE 防腐层的效果对比

焦光伟, 张冲, 祁志江, 王庆 - 重庆理工大学学报(自然科学), 2017 - clgzk.qks.cqut.edu.cn
3PE 防腐层的剥离是管道抢维修作业中的重要环节, 采用后混式磨料水射流剥离3PE
防腐层相比传统方法和前混式磨料水射流具有一定优势. 在后混式磨料水射流剥离3PE …

Scaling behavior of drug transport and absorption in in silico cerebral capillary networks

W Langhoff, A Riggs, P Hinow - PLoS One, 2018 - journals.plos.org
Drug delivery to the brain is challenging due to the presence of the blood-brain barrier.
Mathematical modeling and simulation are essential tools for the deeper understanding of …

Étude des altérations fonctionnelles des cellules endothéliales cérébrales en condition hyperglycémique associée au diabète: rôle protecteur des polyphénols de …

J Taïlé - 2021 - theses.hal.science
Au cours du diabète, l'hyperglycémie provoque des altérations du système vasculaire
aggravant les complications cérébrovasculaires comme l'accident vasculaire cérébral. En …

[PDF][PDF] 基于血脑屏障药物渗透机制的建模与分析

王瑜, 尹智勇 - Journal of Chongqing University of Technology …, 2017 - core.ac.uk
由于血脑屏障结构的特殊性, 脑内疾病的治疗仍然是临床诊疗的一个难点. 一般情况下,
病人只能通过口服或注射药物来治疗这类疾病. 采用理论分析和数值模拟相结合的方法 …

[图书][B] Parameter Estimation for Particle Transport across Blood Brain Barrier Using Machine Learning

AI Khan - 2022 - search.proquest.com
Blood-brain barrier (BBB) is a unique structure in the central nervous system (CNS) that
protects the brain from blood borne pathogens. Despites the protection of BBB, millions of …

Modeling of Anticancer Drug Delivery By Temperature-Sensitive Liposomes

VF Loeser - 2017 - search.proquest.com
Cytotoxic anticancer drugs are used to treat cancer, particularly tumors. These drugs
themselves do not distinguish between healthy and tumor cells and attack all of them …