Hypoxia occurs in solid tumours due to a mismatch between tumour growth and
angiogenesis. Hypoxia in solid tumours is associated with an aggressive phenotype and …

N-terminal acetylation (NTA) is one of the most abundant protein modifications known, and
the N-terminal acetyltransferase (NAT) machinery is conserved throughout all Eukarya. Over …

To survive in hypoxic environments, organisms must be able to cope with redox imbalance
and oxygen deficiency. The SIRT1 deacetylase and the HIF-1α transcription factor act as …

N-terminal modifications play a major role in the fate of proteins in terms of activity, stability,
or subcellular compartmentalization. Such modifications remain poorly described and badly …

The expression of metastasis‐associated protein 1 (MTA1) correlates well with tumor
metastases; however, the associated molecular mechanism is not fully understood. Here, we …

Heat shock protein (Hsp) 70 is a molecular chaperone that maintains protein homoeostasis
during cellular stress through two opposing mechanisms: protein refolding and degradation …

Introduction Lenz microphthalmia syndrome (LMS) is a genetically heterogeneous X-linked
disorder characterised by microphthalmia/anophthalmia, skeletal abnormalities …

The development and growth of a normal prostate gland, as well as its physiological
functions, are regulated by the actions of androgens through androgen receptor (AR) …

ARD1 and NAT1 constitute an N‐acetyltransferase complex where ARD1 holds the
enzymatic activity of the complex. The ARD1–NAT1 complex mediates N‐terminal …

Although a splice variant of mouse mARD1s was found to acetylate and destabilize hypoxia-
inducible factor-1α (HIF-1α), human hARD1 has no such activities. Nonetheless, hARD1 has …